Sökning: "pglycoprotein"

Hittade 2 avhandlingar innehållade ordet pglycoprotein.

1. 1. Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines

   Författare :Kerstin Jönsson Videsäter; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Multidrug resistance; cross-resistance profile; ATP-bioluminescence assay; pglycoprotein; MRP1; selenium; thioredoxin reductase; glutathione reductase.;

   Sammanfattning : Treatment failure due to development of drug resistance is a serious complication in cancer treatment and the major cause of death in these patients. This thesis has focused on to gain knowledge about the mechanisms of multidrug resistance and to establish in vitro methods to characterize the resistant tumor cell phenotype. LÄS MER

3. 2. Drug resistance in acute myeloid leukemia : clinical and experimental studies

   Författare :Bertil Uggla; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The long-term result of chemotherapy in acute myeloid leukemia (AML) is poor, even though a majority of AML patients initially respond to chemotherapy and achieve complete remission (CR). Initially resistant disease as well as relapse is a result of resistance to chemotherapy drug resistance. LÄS MER