Sökning: "peripheral aberrations"

Visar resultat 16 - 20 av 32 avhandlingar innehållade orden peripheral aberrations.

  1. 16. bHLH transcription factors in differentiating neuroblastoma cells

    Författare :Anna Grynfeld; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bHLH; Neuroblastoma; HES-1; HASH-1; N-Myc; differentiation; Mad; Medicine human and vertebrates ; Medicin människa och djur ;

    Sammanfattning : Neuroblastoma is a tumor of the sympathetic nervous system, and arises during early childhood. The tumor is highly heterogeneous and evidence, such as expression of genes normally only expressed during embryonic and fetal stages, suggests that the tumor is of embryonic origin and that the tumor arises as a consequence of perturbed differentiation during the development of the sympathetic nervous system. LÄS MER

  3. 17. Cellular effects after exposure to mixed beams of ionizing radiation

    Författare :Elina Staaf; Andrzej Wojcik; Siamak Haghdoost; Eva Forssell-Aronsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ionizing radiation; high LET; low LET; mixed beams; combined exposure; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Mixed beams of ionizing radiation in our environment originate from space, the bedrock and our own houses. Radiotherapy patients treated with boron neutron capture therapy or with high energy photons are also exposed to mixed beams of gamma radiation and neutrons. LÄS MER

  4. 18. Regulation of neurotrophic signaling molecules in motor neurons, primary sensory neurons and target tissues in senescence

    Författare :Yu Ming; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aging; dorsal root ganglion; spinal cord; muscle; neurotrophins; GFRalpha; Ret; FGF-2; gp 130; CNTF; LIF; IL-6; receptors; protein; mRNA; glia; axon dystrophy; demyelination.;

    Sammanfattning : A hallmark of senescence is sensorimotor impairment, characterized by gait disturbance, deficits in postural control, and muscle weakness. The object of this thesis work was to elucidate some of the molecular basis underlying these disturbances, mainly referring to the occurrence of characteristic changes in gene-expression pattern, especially, alterations in trophic signaling associated with the phenotypic changes seen in motoneurons as well as primary sensory neurons and target muscles during aging. LÄS MER

  5. 19. Leukocyte transmigration and gene expression in healthy subjects and patients with renal failure-application of the skin chamber technique

    Författare :Elham Dadfar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Renal failure; inflammation; skin chamber technique; leukocytes; adhesion mulecules;

    Sammanfattning : The migration of leukocytes from the peripheral circulation into infected or injured tissue is a fundamental step in the host-defense mechanism. The skin chamber technique is a well documented method for studies of leukocyte trans migration and function in vivo. LÄS MER

  7. 20. Exposure, telomere length, and cancer risk

    Författare :Huiqi Li; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; exposure; telomere; methylation; chromosomal aberration; cancer risk; rubber fumes; arsenic; welding fumes; diesel exhaust; particulate matter;

    Sammanfattning : Telomeres are tandem repeats of TTAGGG at the end of eukaryotic chromosomes. Telomeres play a key role in chromosome stability and regulation of the cellular lifespan. Telomeres are shortened during cell division, and probably, by not yet well characterised factors in the environment. LÄS MER