Sökning: "periaqueductal gray"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden periaqueductal gray.

  1. 1. Interactions with pain-related systems - Towards new electrical treatments for chronic pain

    Författare :Matilde Forni; NanoLund: Centre for Nanoscience; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High definition brain stimulation; Periaqueductal gray matter; Pain systems; Pain models;

    Sammanfattning : Background. Persistent intolerable pain is still an unsolved issue with a huge socioeconomic impact. To develop appropriate treatments, it is crucial to understand the complex mechanisms underlying pain and how they change during sustained pain stimuli or during pathological conditions. LÄS MER

  3. 2. Neurotransmission in CNS regions involved in pain modulation : neurochemical effects of analgesic drugs and spinal cord stimulation in the spinal cord and midbrain periaqueductal grey of the rat

    Författare :Carl-Olav Stiller; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adenosine; dorsal horn; GABA; microdialysis; neurotensin; opioids; periaqueductal gray; sciatic nerve lesion; receptor binding; spinal cord stimulation; substance P.;

    Sammanfattning : The dorsal hom of the spinal cord and the midbrain penaqueductal grey matter (PAG) are important regions for pain modulation. In this thesis the effects of opioids and spinal cord stimulation (SCS) on the release of gamma-amino butyric acid (GABA), substance P (SP) and neurotensin (NT) were investigated in these regions of the rat by in vivo microdialysis. LÄS MER

  4. 3. Substance P Endopeptidase : Purification and Characterizataion of Enzyme Activity and Evaluation of its Function during Stressful Condition

    Författare :Krister Karlsson; Lars Oreland; Fred Nyberg; Tsukasa Sakurada; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Substance P Endopeptidase; Neuropeptide; Central Nervous System; Purification; Drug Dependence; Heat Stress; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Sammanfattning : The purification and biochemical characterization of the substance P (SP) hydrolyzing enzyme, substance P endopeptidase (SPE), have been carried out; with subsequent orientation in neurobiological fundamental processes involved in opioid dependence, withdrawal, and heat-stress.SPE was purified from rat spinal cord, human spinal cord and cerebrospinal fluid (CSF), rat ventral tegemental area (VTA), and rat hippocampus. LÄS MER

  5. 4. Fear, Startle, and Fear-Potentiated Startle : Probing Emotion in the Human Brain

    Författare :Anna Pissiota; Mats Fredrikson; Scott Rauch; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Psychology; anxiety; attention; brain; fear; fear-potentiated startle; human; neuroimaging; positron emission tomography; posttraumatic stress disorder; regional cerebral blood flow; startle; startle habituation; symptom provocation; Psykologi; Psychology; Psykologi; Psychology; psykologi;

    Sammanfattning : The present thesis explored the neurobiological basis of three aspects of defense behaviors in humans. Positron emission tomography methodology was used, and changes in regional cerebral blood flow (rCBF) were measured as an index of neural activity. LÄS MER

  7. 5. Imaging Chronic Pain and Inflammation : Positron Emission Tomography Studies of Whiplash Associated Disorder

    Författare :Clas Linnman; Mats Fredrikson; Tomas Furmark; Israel Liberzon; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Whiplash Associated Disorder; PET; brain; chronic pain; rCBF; neurokinin-1; Substance P; inflammation; D-deprenyl; fear of movement; kinesiophobia; ; Psychology; Psykologi;

    Sammanfattning : This thesis is on chronic neck pain after a rear impact car injury, so called whiplash associated disorder (WAD). Three empirical studies using positron emission tomography (PET) with different radioligands have been performed. LÄS MER