Sökning: "perfused-forearm model"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden perfused-forearm model.

  1. 1. Endogenous tissue-type plasminogen activator andendothelial function in vivo. A clinical perspective

    Författare :Thorarinn Gudnason; Göteborgs universitet; []
    Nyckelord :tissue-type plasminogen activator; endothelial function; age; vasodilation; chronic heart failure; coronary artery disease; local regulation; perfused-forearm model;

    Sammanfattning : Endogenous fibrinolysis is initiated by the glycoprotein tissue-type plasminogen activator (tPA), which is released from the vascular endothelium. Plasminogen activator inhibitor type 1 (PAI-1) is the main inhibitor of tPA. LÄS MER

  3. 2. Epigenetic influence on cardiovascular protective mechanisms in vivo: explorations of t-PA release and extracellular vesicle genetic content

    Författare :Kristina Svennerholm; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; myocardial ischemia; epigenetics; histone deactylase inhibition; t-PA; extracellular vesicles; ischemic preconditioning;

    Sammanfattning : ABSTRACT Background: Ischemic heart disease is one of the leading causes of death globally. This thesis explores endogenous mechanisms protecting against myocardial ischemia in context of epigenetics (changes in gene activity not caused by changes in DNA sequences). LÄS MER

  4. 3. Blood Pressure Elevation - Impact on Cardiovascular Structure and Endogenous Fibrinolysis

    Författare :Wilhelm Ridderstråle; Göteborgs universitet; []
    Nyckelord :hypertension; left ventricular hypertrophy; intima-media thickness; fibrinolysis; endothelium; tissue plasminogen activator; antihypertensive agents; mechanical stress; plasminogen activator inhibitor-1;

    Sammanfattning : Blood pressure elevation is a major risk factor for cardiovascular events and the risk increases in a dose-dependant manner. It is of importance to identify subjects prone to develop hypertension and adverse cardiovascular remodeling in order to start treatment timely. LÄS MER

  5. 4. Local regulation of the endogenous fibrinolytic system in man

    Författare :Thordis Hrafnkelsdottir; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tissue-type plasminogen activator; plasminogen activator inhibitor type-1; endothelium; extracellular nucleotides; hypertension; chronic renal failure;

    Sammanfattning : The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (tPA). The endothelium synthesises and stores tPA and regulated release of the enzyme is an important mechanism for removal of fibrin from blood vessels. Plasminogen activator inhibitor type-1 (PAI-1) is the main inhibitor of tPA. LÄS MER

  7. 5. Impairment of Endothelial Thromboprotective Function by Haemodynamic and Inflammatory Stress - Implications for hypertensive disease

    Författare :Erik Ulfhammer; Göteborgs universitet; []
    Nyckelord :tissue-type plasminogen activator; endothelium; fibrinolysis; hypertension; shear stress; strain; antihypertensive agents; inflammation; TNF-alpha; NF-kappaB; MAPK;

    Sammanfattning : The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (t-PA). The endothelium synthesizes and stores t-PA and regulated release of the enzyme is an important local protective response to prevent thrombus extension. LÄS MER