Sökning: "p21 WAF1"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden p21 WAF1.
1. Squamous cell carcinomas and preneoplastic lesions of the oral cavity : biological factors and prognosis
Sammanfattning : In Sweden, squamous cell carcinoma of the oral cavity comprises only 0.8% of the total cancer incidence. However, this disease often has a poor prognosis and the treatment frequently means some degree of disfiguration of the patient. LÄS MER
2. Prognostic markers in breast cancer associated with cell cycle control, proliferation and angiogenesis
Sammanfattning : This thesis focuses on potential prognostic molecular breast cancer markers which are related to angiogenesis, proliferation or cell cycle control. A common denominator for all of the investigated markers in the thesis is either hypothesized or previously reported association with the tumor suppressor gene TP53. LÄS MER
3. Genomic changes defining the progression of human colorectal and cervical tumors
Sammanfattning : Defining changes during the carcinogenesis and progression of tumors is a major way to obtain a better understanding of the mechanisms of cancer development. We therefore investigated the carcinogenesis process in the colon-rectum and in the uterine cervix by different cell chemical, immunohistochemical and cytogenetic methods. LÄS MER
4. Radiation-induced apoptosis in human lymphocytes : studies on expression, function and effects of different radiation qualities
Sammanfattning : We are constantly exposed to radiation. Radiation causes damage to our cells. By the removal of damaged and unwanted cells, apoptosis is considered to be one of the most indispensable defence processes for a multi-cellular organism. LÄS MER
5. Genetic changes in childhood acute lymphoblastic leukaemia and other lymphoid malignancies
Sammanfattning : Malignant transformation of normal cells is the result of defects in cell growth control, differentiation and programmed cell death. It has been convincingly shown that malignant cells carry mutations in the genes controlling these cellular processes. LÄS MER