Sökning: "oxime"

Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet oxime.

  1. 1. Design strategies for new drugs targeting multicomponent systems : focusing on class II MHC proteins and acetylcholinesterase

    Författare :Cecilia Lindgren; Anna Linusson; Antti Poso; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; class II MHC protein; drug design; molecular dynamics simulation; multicomponent system; nerve agent; oxime; quantitative structure-activity relationship; reactivator; rheumatoid arthritis; statistical molecular design; T-cell receptor;

    Sammanfattning : The field of medicinal chemistry is constantly evolving. Aided by advances within techniques as well as knowledge of biological systems, increasingly complex targets and drugs can be considered. LÄS MER

  3. 2. Reaction Between Grignard reagents and Heterocyclic N-oxides : Synthesis of Substituted Pyridines, Piperidines and Piperazines

    Författare :Hans Andersson; Fredrik Almqvist; Hans Adolfsson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Grignard reagents; pyridine N-oxide; pyrazine N-oxide; dienal-oxime; pyridine; ortho- metalation; piperidine; piperazine; asymmetric; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis describes the development of new synthetic methodologies for preparation of bioactive interesting compounds, e.g. substituted pyridines, piperidines or piparazines. Thesecompounds are synthesized from commercially available, cheap and easily prepared reagents, videlicet the reaction between Grignard reagents and heterocyclic N-oxides. LÄS MER

  4. 3. Bioactivation of Xenobiotics in the Skin. Mechanistic Investigations and Structure-Activity Relationship Studies of Alkene and Oxime Prohaptens in Contact Allergy

    Författare :Moa Andresen Bergström; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  5. 4. Mitochondrial dysfunction and alterations of brain HMPAO SPECT in depressive disorder : perspectives on origins of 'somatization'

    Författare :Ann Gardner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :99mTc-d; 1-hexamethylpropyleneamine oxime; clinical rating scales; hearing loss; mtDNA; muscle biopsy; PCR; single photon emission computed tomography; tinnitus; unipolar depression.;

    Sammanfattning : A range of somatic symptoms are more common in patients with major depression than in the general population. Similar somatic symptoms and depression have been described in mitochondrial disorders, in which decreased production of adenosine triphosphate (ATP) is found. LÄS MER

  7. 5. Gas chromatography - mass spectrometry of sugars and related hydroxy acids as trimethylsilyl derivatives

    Författare :Göran Petersson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; mass spectrometry; hydroxy acids; gas chromatography; pulping; monosaccharides;

    Sammanfattning : The application of gas chromatography and mass spectrometry has contributed to the rapid progressof carbohydrate chemistry during the past ten years. Themethods are indispensable tools in current research oncarbohydrate reactions during pulping processes. LÄS MER