Sökning: "ovarian carcinoma"

Visar resultat 16 - 20 av 44 avhandlingar innehållade orden ovarian carcinoma.

  1. 16. Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations

    Författare :Susanne Magnusson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Childhood cancer; hereditary factors; breast cancer; survival; hereditary breast and ovarian cancer; hereditary non-polyposis colorectal cancer; familial malignant melanoma; BRCA1; BRCA2; mismatch repair; CDKN2A; familial risk; multiple childhood tumors; Li-Fraumeni syndrome; TP53; adrenocortical carcinoma; choroid plexus tumors; rhabdomyosarcoma;

    Sammanfattning : The etiology of childhood cancer is largely unknown. Approximately 1-10% of all childhood tumors are associated with known cancer predisposition syndromes. However, the contribution may be underestimated due to the failure to detect patients with genetic susceptibility for cancer when relying on known family pattern and anomalies. LÄS MER

  3. 17. Ovarian tumours, cell isolation, cell survival and sex steroids

    Författare :Magdalena Taube; Seija Grénman; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; Obstetrik och gynekologi; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : Background: Ovarian cancer is the most deadly malignancy of the female reproductive tract. Ovarian epithelial tumours are considered to be endocrine related, but the factors that govern their genesis and progression remain unclear. Radical surgery and recent advances in chemotherapy have only moderately improved survival rates. LÄS MER

  4. 18. Predictive and prognostic factors of epithelial ovarian cancer and pseudomyxoma peritonei

    Författare :Kathrine Bjersand; Inger Sundström Poromaa; Pernilla Dahm Kähler; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : The overall aim of my thesis was to investigate potential prognostic and predictive factors associated with the tumor cells of epithelial ovarian cancer (EOC) and the gastrointestinal tumor pseudomyxoma peritonei (PMP) to improve and individualize cancer therapy. Both PMP and EOC can develop into peritoneal carcinomatosis (PC), which is characterized by widespread metastasis of cancer tumors in the peritoneal cavity. LÄS MER

  5. 19. Precision medicine of ovarian cancer for adults and children : molecular, hereditary and clinical aspects

    Författare :Sandra Wessman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Ovarian cancer was 2018 ranked as the eighth most common cancer diagnosis and cause of death in women. Of these, the most common histological type is high-grade serous carcinoma. LÄS MER

  7. 20. Receptor tyrosine kinase signaling and extracellular matrix cues in ovarian cancer metastasis and drug resistance

    Författare :Lidia Moyano Galceran; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Albeit many studies have contributed towards understanding the origin, development, treatment response and evolution of high-grade serous ovarian carcinoma (HGSC), the exact supporting mechanisms are still not fully understood, and the disease remains a clinical challenge with low 5-year survival and high recurrence rate. The purpose of this thesis was to study the dynamic communication between the cancer cells and the tumor microenvironment (TME) to understand how these influence and are affected by disease progression and chemotherapy in the context of HGSC. LÄS MER