Sökning: "osteopontin"

Visar resultat 11 - 15 av 41 avhandlingar innehållade ordet osteopontin.

1. 11. Methods for protein analysis by capillary electrophoresis and mass spectrometry

   Författare :Joakim Romson; Åsa Emmer; Peter Dinér; Lukas Käll; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MALDI; Concentration plates; Alkyl ketene dimer; CE-MALDI-MS2; On-target digestion; Automation; Robot; Pieris napi; spermatophore; ESI-MS2; Osteopontin; MALDI; Koncentrationsprovplatta; alkylketenedimer; CE-MALDI-MS2; enzymklyvning på provplatta; Automatisering; Robot; Pieris napi; Spermatofor; ESI-MS2; Osteopontin; Kemi; Chemistry;

   Sammanfattning : Protein analysis is important to understanding biological systems, but sample diversity necessitates a multitude of analysis techniques and methods. Challenges that are addressed include analysis of low abundance samples, fractionation to reduce sample complexity, and automation to reduce time and cost. LÄS MER

3. 12. Matrix resorption in endochondral bone growth : ultrastructural studies, with special attention to the chondroclast

   Författare :Joakim Nordahl; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :chondroclast; osteoclast; cartilage resorption; TRAP; cathepsin K; fibronectin; bone sialoprotein; osteopontin;

   Sammanfattning : A substantial amount of the calcified cartilage in the distal parts of the epiphyseal plate is resorbed during endochondral growth of long bones. However, the mechanisms involved in this process are still largely unknown. On the other hand, bone-resorption in the lower metaphysis has been thoroughly investigated. LÄS MER

4. 13. Functional role of a constitutively active dioxin/Ah receptor in a transgenic mouse model

   Författare :Patrik Andersson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Dioxin Ah receptor; TCDD; dioxin; stomach tumor; osteopontin; peritoneal B1 B cells; transcription factor; gene expression;

   Sammanfattning : The dioxin/ Aryl hydrocarbon receptor is a ligand-activated transcription factor that mediates most (if not all) of the toxic effects of the group of highly potent environmental pollutants collectively called dioxins and PCBs, including the highly toxic compound 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD). The toxic effects include immune suppression, endocrine disruption, impaired reproduction and carcinogenesis. LÄS MER

5. 14. Studies on anti-dsDNA Antibodies and other potential biomarkers in Systemic Lupus Erythematosus

   Författare :Michele Compagno; Reumatologi och molekylär skelettbiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic Lupus Erythematosus Anti-dsDNA antibodies Biomarkers Osteopontin S100A8 A9 LE-cells Diagnostic accuracy Longitudinal study Multicentre study;

   Sammanfattning : Systemic Lupus Erythematosus (SLE) is characterized by chronic inflammation involving many organ systems. The etiology is unknown and the pathogenesis has not been fully elucidated. Impairments of the immune system and of the mechanisms regulating cell death are commonly seen in SLE patients. LÄS MER

7. 15. Genomic clues to secondary injury mechanisms in brain trauma

   Författare :Christina von Gertten; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :traumatic brain injury; cerebral cortical contusion; weight-drop model; depolarisation; gene expression; nestin; MMP-9; TIMP-1; osteopontin; CD44; hippocalcin; NMDA receptor; microarray; rat;

   Sammanfattning : Traumatic brain injury (TBI) is a heterogenous disease that can lead to persistent disability or death. The immediate mechanical disruption of brain tissue is followed by a phase of secondary brain injury. During this phase TBI challenges clinical interventions due to its complexity. LÄS MER