Sökning: "ortholog"

Visar resultat 16 - 20 av 44 avhandlingar innehållade ordet ortholog.

  1. 16. Inference of functional association networks and gene orthology

    Författare :Thomas Schmitt; Erik L. L. Sonnhammer; Søren Brunak; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; orthology; InParanoid; FunCoup; systems biology; biological networks; network inference; functional coupling; functional association; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

    Sammanfattning : Most proteomics and genomics experiments are performed on a small set of well-studied model organisms and their results are generalized to other species. This is possible because all species are evolutionarily related. When transferring information across species, orthologs are the most likely candidates for functional equivalence. LÄS MER

  3. 17. Characterization of a putative tumor suppressor region identified by the elimination test on human 3p21.3

    Författare :Hajnalka Kiss; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Elimination test; common eliminated region 1 CER1 ; 3p21.3; tumor suppressor gene; large scale sequencing; LIMD1; LZTFL1; FYC01; TMEM7; LRRC2; LUZP3.;

    Sammanfattning : An experimental system, called the elimination test (Et), was developed to identify tumor growth antagonizing genes. Chromosome 3 containing microcell hybrids (MCHs) were passaged through SCID mice and regular deletion of the short arm of chromosome 3 (3p) were found by cytogenetic and molecular methods. LÄS MER

  4. 18. The role of hnRNP A1 and hnRNP C1/C2 in the regulation of the stress responsive genes Cyp2a5/2A6 and p53

    Författare :Kyle Christian; Matti Lang; Françoise Raffalli-Mathieu; Kirsi Vähägangas; Uppsala universitet; []
    Nyckelord :Molecular biology; hnRNP; Tumor Suppressor Protein p53; CYP2A5; CYP2A6; Apoptosis; hnRNP C Proteins; hnRNP protein A1; Cancer; Molekylärbiologi;

    Sammanfattning : The family of proteins known as heterogeneous nuclear ribonucleoproteins (hnRNPs) is large and diverse. Often, one and the same hnRNP will perform multiple cellular functions, leading to their description as “multifunctional proteins”. LÄS MER

  5. 19. Evolution of a family of plant genes with regulatory functions in development; studies on Picea abies and Lycopodium annotinum

    Författare :Mats Svensson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; fysiologisk botanik; Physiological Botany;

    Sammanfattning : This work is focused on the molecular genetic basis for morphological change in evolution. Genes belonging to the MADS-box gene family, which includes members, that determine angiosperm floral organ identity, were isolated and characterised from two non-angiosperm plants; Norway spruce (Picea abies) and the club moss (Lycopodium annotinum). LÄS MER

  7. 20. Dynamic control of the yeast AMPK/SNF1 pathway in response to glucose signals

    Författare :Loubna Bendrioua; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; AMPK; SNF1; Mig1; glucose signalling; dynamic control; mechanism; Saccharomyces cerevisiae;

    Sammanfattning : The SNF1/AMP-activated protein kinase (AMPK) belongs to a family of energy sensors that is conserved in all eukaryotes. Activated by ATP depletion, AMPK plays a vital role in restoring the energy balance by enhancing energy-generating and damping energy-requiring processes. LÄS MER