Sökning: "oral vaccination"
Visar resultat 1 - 5 av 24 avhandlingar innehållade orden oral vaccination.
1. Development of a New Oral Vaccine against Diphtheria and the Study of its Immunogenicity in Mouse and Man
Sammanfattning : Most pathogens enter the body via mucosal surfaces. In contrast to parenterally administered vaccination, mucosal vaccination has the advantage of eliciting both a systemic and a local mucosal immune response. An oral biodegradable adjuvant with these features would have great potential. LÄS MER
2. Particle Transcytosis Across the Human Intestinal Epithelium : Model Development and Target Identification for Improved Drug Delivery
Sammanfattning : The use of nano- and micro-particulate carriers as delivery systems for oral vaccines has been under investigation for several decades. Surprisingly little is known of their uptake in the human intestine, despite the fact that substantial improvement is required to achieve adequate immune responses in man after oral administration. LÄS MER
3. Broadly protective nanoparticle-based mucosal vaccine against influenza virus infection
Sammanfattning : Influenza is one of the major viral diseases affecting humans and it is responsible for three to five million cases of severe illness and about 250.000 to 500.000 deaths each year worldwide. LÄS MER
4. Antibody responses in genital secretions and serum after mucosal vaccination in humans
Sammanfattning : The overall aim of this thesis was to study the induction of B-cell immune responses in genital secretion and serum after mucosal vaccination in women. Oral inactivated B subunit whole-cell (B-WC) cholera vaccine and recombinant cholera toxin B subunit (CTB) alone were used as model immunogens. LÄS MER
5. B- and T- cell responses in colectomized and healthy individuals after mucosal vaccination
Sammanfattning : The overall aims were to study the induction of intestinal and systemic B- and T-cell immune responses in patients colectomized due to ulcerative colitis and in healthy volunteers after mucosal administration of enteric vaccines. An inactivated B-subunit whole-cell (B-WC) cholera vaccine and a live attenuated Salmonella enterica serovar Typhi Ty21a vaccine were used as model immunogens. LÄS MER