Sökning: "onset of action"

Visar resultat 1 - 5 av 88 avhandlingar innehållade orden onset of action.

  1. 1. Metabolomics studies of ALS : a multivariate search for clues about a devastating disease

    Författare :Anna Wuolikainen; Peter M Andersen; Henrik Antti; Stefan L Marklund; Thomas Moritz; Thomas Hankemeier; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyotrophic lateral sclerosis ALS ; motor neuron disease; Lou Gehrig’s disease; human disease; CSF; biomarkers; metabolomics; metabonomics; chemometrics; design of experiments; multivariate analysis.; Neurology; Neurologi; Neurology; neurologi;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS), also known as Charcot’s disease, motor neuron disease (MND) and Lou Gehrig’s disease, is a deadly, adult-onset neurodegenerative disorder characterized by progressive loss of upper and lower motor neurons, resulting in evolving paresis of the linked muscles. ALS is defined by classical features of the disease, but may present as a wide spectrum of phenotypes. LÄS MER

  3. 2. Factors influencing the risk of diabetic nephropathy : analyses of genes, smoking and diet

    Författare :Anna Möllsten; Gisela Dahlquist; Lise Tarnow; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 1 diabetes; diabetic nephropathy; oxidative stress; smoking; diet; blood pressure; renin-angiotensin system; nitric oxide synthase; Kidney diseases; Njursjukdomar;

    Sammanfattning : Diabetic long-term complications, despite intensive treatment, cause serious handicaps at relatively young age in diabetic patients. Diabetic nephropathy (DN) develops in up to 30% of patients with type 1 diabetes (T1D). LÄS MER

  4. 3. “Dr Jekyll and Mr Hyde?” : Abuse of potent benzodiazepines, exemplified by flunitrazepam, in mentally disordered male offenders

    Författare :Anna Maria Dåderman; Marianne Kristiansson; Lars Lidberg; Ann Wirsén Meurling; Sten Levander; Fred Nyberg; Karolinska Institutet Division of Forensic Psychiatry Department of Clinical Neuroscience; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Flunitrazepam FZ abuse; side effects of FZ; offenders referred to forensic psychiatric evaluation; juvenile delinquents; personality traits; psychopathic traits and lifestyle PCL-R ; Psychology; Psykologi; Flunitrazepam FZ abuse; side effects of FZ; offenders referred to forensic psychiatric evaluation; juvenile delinquents; personality traits; psychopathic traits and lifestyle PCL-R .;

    Sammanfattning : Flunitrazepam (FZ) is an example of a sedative-hypnotic benzodiazepine whose pharmacokinetic properties include a rapid onset of action and an intermediate duration of action. It has a high affinity to central benzodiazepine receptors and affects them profoundly. LÄS MER

  5. 4. Mode of action of asenapine vs. other antipsychotic drugs : an experimental analysis

    Författare :Olivia Frånberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Antipsychotic drugs (APDs) are used in the treatment of schizophrenia and manic or mixed episodes associated with bipolar I disorder. Generally, the so-called atypical APDs, such as clozapine, may in contrast to typical APDs improve not only positive, but also negative symptoms and some aspects of cognitive impairment associated with schizophrenia. LÄS MER

  7. 5. Developmental Neurotoxicity of Environmental Pollutants : Effects on neuronal protein markers after neonatal exposure

    Författare :Iwa Lee; Henrik Viberg; Elena Jazin; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental neurotoxicity; Neonatal exposure; Protein markers; Environmental pollutants; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Sammanfattning : This thesis focused on investigations of the developmental neurotoxic effects of bisphenol A (BPA) or perfluorohexane sulfonate (PFHxS), after a single neonatal exposure, during a critical period of the brain development in mice.BPA is a well-known industrial chemical used in the production of polymer products and PFHxS is used as an industrial additive as a surfactant. LÄS MER