Sökning: "normal tissue damage"
Visar resultat 1 - 5 av 130 avhandlingar innehållade orden normal tissue damage.
1. DNA Damage Response of Normal Epidermis in the Clinical Setting of Fractionated Radiotherapy : Evidence of a preserved low-dose hypersensitivity response
Sammanfattning : Investigations of DNA damage response (DDR) mechanisms in normal tissues have implications for both cancer prevention and treatments. The accumulating knowledge about protein function and molecular markers makes it possible to directly trace and interpret cellular DDR in a tissue context. LÄS MER
2. Quantification of Radiation Induced DNA Damage Response in Normal Skin Exposed in Clinical Settings
Sammanfattning : The structure, function and accessibility of epidermal skin provide aunique opportunity to study the DNA damage response (DDR) of a normaltissue. The in vivo response can be examined in detail, at a molecularlevel, and further associated to the structural changes, observed at atissue level. LÄS MER
3. Improved dose response modeling for normal tissue damage and therapy optimization
Sammanfattning : The present thesis is focused on the development and application of dose response models for radiation therapy. Radiobiological models of tissue response to radiation are an integral part of the radiotherapeutic process and a powerful tool to optimize tumor control and minimize damage to healthy tissues for use in clinical trials. LÄS MER
4. Clincal Aspects of Biological Brain Damage Markers
Sammanfattning : Biomarkers for organ damage and/or dysfuntion are used in almost all areas of medicine. The brain has eluded this technological development for some time. Recently, the S100B protein has been shown to be a promising marker of brain damage. However, before S100S can reach clinical reality, several problems must be solved. LÄS MER
5. The involvement of the TNF-alpha system in skeletal muscle in response to marked overuse
Sammanfattning : Painful conditions having the origin within the musculoskeletal system is a common cause for people to seek medical care. Between 20-40% of all visits to the primal care in Sweden are coupled to pain from the musculoskeletal system. Muscle pain and impaired muscle function can be caused by muscles being repetitively overused and/or via heavy load. LÄS MER