Sökning: "non-BRCA1 BRCA2"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden non-BRCA1 BRCA2.

  1. 1. Gene Expression Profiling of Hereditary Breast Cancer

    Författare :Ingrid Hedenfalk; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; non-BRCA1 BRCA2; BRCAx; MYB; cDNA microarray; gene expression profiling; tissue microarray; Cytology; oncology; cancerology; Cytologi; cancer; onkologi; BRCA2; Hereditary breast cancer; BRCA1;

    Sammanfattning : [abstract missing].... LÄS MER

  3. 2. Investigation of the genetic basis of familial non-BRCA1/2 breast cancer

    Författare :Paula Maguire; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Familial non-BRCA1 2 breast cancer; linkage analysis; CGH; association study;

    Sammanfattning : Breast cancer is the most common female malignancy in the Western world and approximately 510% of all breast cancer cases present with some degree of family history. In the mid-nineties genetic linkage analyses successfully identified two breast cancer predisposing genes, BRCA1 and BRCA2. LÄS MER

  4. 3. On the genetics of hereditary breast/ovarian cancer. BRCA1, BRCA2 and beyond

    Författare :Annika Bergman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BRCA1; BRCA2; breast cancer; hereditary cancer; founder mutation; mutation analysis; linkage analysis; genome scan; BRCAX;

    Sammanfattning : Breast cancer is the most common malignancy in women. Most of the breast cancers are sporadic with no apparent inheritance factor but about 5-10% is believed to be caused by an inherited predisposition. Aims: This thesis aimed at defining the BRCA1/2 mutation spectrum of the west Swedish population and specifically to characterize the BRCA1c. LÄS MER

  5. 4. Family history and breast cancer susceptibility : clinical and molecular studies

    Författare :Sara Margolin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :breast cancer; family history; sporadic; familial; BR CA 1; CHEK2; polymorphism; association; estrogen receptor alpha; estrogen receptor beta;

    Sammanfattning : Apart from gender, family history is the most important risk factor for breast cancer. In 5-10 % of the cases there is a family history pattern of an autosomal dominant disease and there is also a familial clustering of breast cancer associated with a more modest increased risk of the disease. LÄS MER

  7. 5. Genetic characterization of malignant melanoma and breast cancer

    Författare :Göran B Jönsson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; microarray; inherited breast cancer; Melanoma; linkage analysis; cancer; Cytologi; cancerology; onkologi;

    Sammanfattning : Malignant melanoma and breast cancer are common malignant diseases characterized by considerable heterogeneity with respect to genetics, histopathology, biology and clinical course. In breast cancer, two major susceptibility genes have been identified, BRCA1 and BRCA2, which account for a significant proportion of high-risk breast cancer families. LÄS MER