Sökning: "neurotransmission"

Visar resultat 1 - 5 av 156 avhandlingar innehållade ordet neurotransmission.

  1. 1. Tryptophan-related Neurotransmission in the Brain: Disturbances Associated with Experimental Hepatic Encephalopathy

    Författare :Peter B F Bergqvist; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tetrodotoxin; serotonin; release; rat; quinolinic acid; potassium; chloroamphetamine; noradrenaline; neurotransmission; microdialysis; hepatic encephalopathy; fenfluramine; drug safety; dopamine; coma; citalopram; ammonia; calcium; brain; tryptophan; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : In the present study, L-tryptophan (TRP)-related disturbances in the brain in experimental hepatic encephalopathy (HE) were investigated. The endogenous NMDA-receptor agonist and L-TRP metabolite quinolinic acid (QUIN) has been suggested to be involved in the pathogenesis of HE. LÄS MER

  3. 2. Studies on nitric oxide in autonomic neurotransmission

    Författare :Caroline Olgart; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :acetylcholine; autonomic neurotransmission; botulinum toxin; colon; guinea pig; ileum; intestine; nitric oxide; rat; tachykinin.;

    Sammanfattning : The aim of the present thesis was to study nitric oxide (NO) as a mediator in autonomic neurotransmission in the enteric nervous system, including studies on the mechanism for neuronal release of NO, as well as the effects of NO on intestinal smooth muscle and enteric neurones. Furthermore, the signal transduction pathway for the evoked effects of NO and nitrergic neurotransmission were investigated. LÄS MER

  4. 3. Behavioural studies on central 5-HT receptor subtypes in the rat : drug-induced changes in 5-HT neurotransmission

    Författare :Lucy Rényi; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  5. 4. PET evaluation of central serotonergic neurotransmission in women

    Författare :Hristina Jovanovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PET; serotonin; 5-HT1A receptor; 5-HTT; WAY100635; MADAM; premenstrual dysphoric disorder; borderline personality disorder; gonadal hormones;

    Sammanfattning : The serotonin (5-HT) system is of central interest in the patophysiology and treatment of several psychiatric disorders including depression, anxiety and suicide. In women, functioning of the 5-HT system is of particular importance since they have been found to suffer more often from 5-HT-associated disorders compared to men. LÄS MER

  7. 5. Galanin : a modulator of serotonin neurotransmission : relevance for depression

    Författare :Haleh Razani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :galanin; 5-HT1A receptors; 5-HT; 8-OH-DPAT; fluoxetine; robalzotan; passive avoidance; microdialysis; mRNA; KD values; Bmax values; depression;

    Sammanfattning : Galanin is widely distributed throughout the central nervous system with multiple and diverse biological roles. In the rat, galanin-like immunoreactivity is expressed in a population of5-hydroxytryptamine (5-HT, serotonin) neurons in the dorsal raphe (DR) with extensive projections to the forebrain areas e.g., hippocampus. LÄS MER