Sökning: "neuronal activity"

Visar resultat 1 - 5 av 416 avhandlingar innehållade orden neuronal activity.

  1. 1. The physiological processing of Alzheimer-associated amyloid beta precursor protein in human and animal-derived neuronal models

    Författare :Tugce Munise Satir; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; APP; Aβ; human iPSCs; cortical neurons; BACE1; PSEN1; neuronal activity; neuronal differentiation;

    Sammanfattning : Alzheimer’s disease (AD) is characterized by cognitive impairment due to the loss of structure and/or function of neurons, and amyloid plaques composed of aggregated-amyloid beta (Aβ) peptides, primarily species ending at the amino acid 42 (Aβ42), are one of the major neuropathological hallmarks of AD. Aβ peptides of different lengths are produced by sequential cleavage of amyloid beta precursor protein (APP) by α-, β- and γ- secretases. LÄS MER

  3. 2. Crossing the Midline : Locomotor Neuronal Circuitry Formation

    Författare :Fatima Memic; Klas Kullander; Avihu Klar; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CPG; CIN; neuronal network; locomotion; left-right alternation;

    Sammanfattning : Networks at various levels of the nervous system coordinate different motor patterns such as respiration, eye or hand movements and locomotion. Intrinsic rhythm-generating networks that are located in the spinal cord generate motor behaviors that underlie locomotion in vertebrates. LÄS MER

  4. 3. The corticogeniculate synapse : a neuronal amplifier?

    Författare :Björn Granseth; Eric Hanse; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Consciousness is a nervous process that handles only a limited amount of information. Therefore the nervous system needs to select the most relevant input for aware processing. LÄS MER

  5. 4. Activity-regulated retinoic acid signaling in olfactory sensory neurons

    Författare :Hande Login; Staffan Bohm; Mattias Alenius; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse olfactory system; RA; neuronal activity; CNG; Cyp26B1; BACE1; Kirrel-2; molekylärbiologi; Molecular Biology;

    Sammanfattning : The aim of the studies included in the thesis is to better understand the interplay between neuronal activity-dependent gene regulation and the bioactive vitamin A metabolite all-trans-retinoic acid (RA) during postnatal development, refinement and maintenance of precise neuronal connectivity using the olfactory sensory neuron (OSN) in the olfactory epithelium (OE) of genetically modified mice as a model. We show that:Inhibition of RA receptor (RAR)-mediated transcription in OSNs reduces expression of the olfactory cyclic nucleotide-gated (CNG) ion channel, which is required for odorant receptor (OR)-mediated stimulus transduction. LÄS MER

  7. 5. On the Autonomic Control of Blood Flow and Secretion in Salivary Glands. Functional and morphological aspects on muscarinic receptor subtypes in different species

    Författare :Anders Ryberg; Göteborgs universitet; []
    Nyckelord :Muscarinic receptor subtype; neuronal; non-neuronal; expression; secretion; blood flow; salivary gland; human; rat; sheep;

    Sammanfattning : Parasympathetic nervous activity is the principal stimulus for evoking fluid responses within salivary glands. Concomitantly to the onset of this response, the blood flow increases. LÄS MER