Sökning: "multiple primary tumors"

Visar resultat 1 - 5 av 53 avhandlingar innehållade orden multiple primary tumors.

1. 1. Multiple primary malignancies in breast cancer patients. From population study to genetics

   Författare :Jenny Nyqvist; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; multiple primary malignancies; genetic alterations;

   Sammanfattning : Breast cancer (BC) is one of the most common causes of cancer-related death among women worldwide. Due to early detection of BC and more tailor-made treatments, patients live longer despite their illness. Studies have shown that BC patients are at risk of developing new tumors in organs other than the breast, mainly caused by BC treatment. LÄS MER

3. 2. Tumors associated with Hereditary Nonpolyposis Colorectal Cancer: Defective Mismatch Repair and Familial Risk of Cancer

   Författare :Kajsa Ericson Lindquist; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; cancerology; Cytologi; onkologi; cancer; Multiple Tumors; Hereditary Nonpolyposis Colorectal Cancer; Cytology; Cohort study; Population based; Familial Risk of Cancer; Immunohistochemistry; MSH2; MSH6; MLH1; Microsatellite Instability; Soft Tissue Sarcomas; Cancer of the Upper Urinary Tract; Cancer of the Small Intestine; Colorectal Cancer;

   Sammanfattning : Inactivation of the DNA mismatch repair (MMR) system is a tumorigenic mechanism involved in 15-20% of tumor types such as colorectal and endometrial cancer and is specifically associated with the Hereditary Nonpolyposis Colorectal Cancer (HNPCC) syndrome. These MMR defective tumors are characterized by microsatellite instability (MSI), a phenomenon that reflects alterations in length of repeated sequences, and 90% of MSI tumors show loss of immunohistochemical expression for the MMR protein affected. LÄS MER

4. 3. Cancer of unknown primary: searching for the etiological clues. A population-based epidemiological study in Sweden

   Författare :Xiaochen Shu; Allmänmedicin och klinisk epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer of unknown primary; causes of death; familial risk; immigrant; incidence; multiple malignancies; risk factor; squamous cell carcinoma; standardizedincidence ratio; survival;

   Sammanfattning : This thesis aimed to search for etiological clues about cancer of unknown primary(CUP) by gathering novel information. The Swedish national registries were used and CUP cases were identified according to the seventh revision of the International Classification of Diseases. LÄS MER

5. 4. Soft Tissue Sarcoma Patterns multiplicity, heterogeneity and growth characteristics

   Författare :Josefin Fernebro; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; Cytologi; oncology; Soft tissue sarcoma; tumor periphery; Medicine human and vertebrates ; Medicin människa och djur ; Cytology; multiple primary tumors; onkologi; cancer;

   Sammanfattning : Soft tissue sarcomas (STS) represent a group of rare and heterogenous tumors that optimally should be diagnosed and treated within multidisciplinary teams. This thesis has studied various aspects ? pathological, genetical, and clinical ? of STS. LÄS MER

7. 5. Immunotherapy and COX-2 inhibition against malignant brain tumors

   Författare :Sofia Eberstål; Neurokirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Malignant brain tumors; immunotherapy; IFN-γ; GM-CSF; COX-2 inhibition;

   Sammanfattning : Glioblastoma multiforme (GBM) is the most common primary brain tumor in the central nervous system and the prognosis is very poor despite conventional therapies including surgery, chemo- and radiotherapy. Peripheral vaccination with irradiated tumor cells represent a novel therapy that targets both dividing and non-dividing tumor cells and minimizes the risk of therapy resistance by presenting multiple tumor antigens. LÄS MER