Sökning: "mucosal immunology"

Visar resultat 1 - 5 av 80 avhandlingar innehållade orden mucosal immunology.

  1. 1. Mucosal Immunity in Mycobacterial infections

    Författare :Anna Tjärnlund; Marita Troye-Blomberg; Andrzej Pawlowski; Anders Örn; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Immunology; Immunologi; immunologi; Immunology;

    Sammanfattning : More than a century after the identification of the tubercle bacillus and the first attempts at vaccination, tuberculosis (TB) still remains one of the world’s most serious infectious diseases. TB, caused by the bacterium Mycobacterium tuberculosis, is typically a disease of the lung, which serves both as port of entry and as the major site of disease manifestation. LÄS MER

  3. 2. Effects of bacterial genotoxins on immune modulation, chronic inflammation and cancer development

    Författare :Anna Bergonzini; Teresa Frisan; Maria Fällman; Steffen Backert; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunologi; Immunology;

    Sammanfattning : The intestinal microbiome of Inflammatory Bowel Disease and colorectal cancer patients is enriched in genotoxin-producing bacteria, which cause DNA damage in the host cells.Genotoxins have recently been identified as a novel family of effectors produced by pathogenic and commensal bacteria. LÄS MER

  4. 3. Lactobacilli- and Staphylococcus aureus mediated modulation of immune responses in vitro

    Författare :Yeneneh Haileselassie; Eva Sverremark-Ekström; Huub Savelkoul; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; lactobacilli; staphylococcus aureus; dendritic cells; retinoic acid; epithelial cells; T cells; immunologi; Immunology;

    Sammanfattning : The human gut harbors a vast number of microbes. These microbes are not passive bystanders. They are important in modulating the immune system. We have previously shown that early colonization with lactobacilli and Staphylococcus (S. LÄS MER

  5. 4. Early-life gut microbiota and breast milk oligosaccharides in relation to childhood immune maturation and allergy

    Författare :Ylva Margareta Sjögren; Eva Sverremark-Ekström; Outi Vaarala; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; allergy; infant; gut microbiota; human milk oligosaccharides; Bifidobacterium; Lactobacillus; Bacteroides fragilis; Clostridium difficile; family size; secretory IgA; toll like receptor; Immunology; Immunologi; immunologi; Immunology;

    Sammanfattning : Atopic allergy is the most common chronic disease among children in the developed world. This high prevalence could be associated with low microbial exposure. The early gut microbiota appears to be important for immune maturation. LÄS MER

  7. 5. Design of solid dosage forms for mucosal vaccination - Investigations on the influence of excipients on product performance

    Författare :Annika Borde; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; hydrophilic matrix tablets; osmotic pressure; protein release; freeze-drying; Vibrio cholerae; mucoadhesion; Bradford Assay; sublingual vaccine tablet; mucosal vaccination;

    Sammanfattning : Most vaccines today are liquid formulations for parental administration. However, there are several drawbacks connected to these vaccines. Since injectable vaccines only induce systemic antibody responses, they are not effective against the various pathogens that affect mucosal surfaces with poor permeability for serum-derived antibodies, e.g. LÄS MER