Sökning: "mucosal barrier integrity"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden mucosal barrier integrity.

  1. 1. Gastrointestinal mucosal protective mechanisms : Mudolatory effects of Heliobacter pyroli on the gastric mucus gel barrier and mucosal blood flow in vivo

    Författare :Christer Atuma; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; mucus gel layer; mucosal blood flow; mucus thickness; chronic infection; rat; platelet activating factor; mast cell; nitric oxide; nitric oxide synthase; ketotifen; intra-vital microscopy; microelectrode; laser-Doppler flowmetry; L-NNA; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Sammanfattning : The gastrointestinal mucus gel layer and blood flow are two important mechanisms for protection at the pre-epithelial and sub-epithelial levels, respectively. Helicobacter pylori might circumvent these mechanisms and elicit a chronic inflammatory response with consequent ulcers in the stomach and duodenum. LÄS MER

  3. 2. Experimental Disruption of Intestinal Mucosal Homeostasis : Exploring the Protective Potential of Melatonin and Misoprostol

    Författare :Karsten Peters; Markus Sjöblom; Hans Lennernäs; David Dahlgren; Åsa Keita; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intestinal barrier dysfunction; intestinal permeability; chemotherapy-induced mucositis; doxorubicin; 5-fluorouracil; apoptosis; proliferation; melatonin; misoprostol; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The intestinal mucosa serves as a protective layer that separates the intestinal contents from the underlying tissues. It restricts harmful substances, pathogens, and undigested particles from entering the bloodstream. LÄS MER

  4. 3. Gastrointestinal Permeability and Motility in Inflammatory Bowel Disease

    Författare :Anas Kh. Al-Saffar; Per Hellström; Dominic-Luc Webb; Åsa Keita; Uppsala universitet; []
    Nyckelord :Gastrointestinal motility; intestinal permeability; Mucosal; Ghrelin; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Synchronized motility, permeability and secretory (hormones and enzymes) events are integral to normal physiology. Smooth muscle syncytium operates with enteric nervous system (ENS) and endocrine signalling to accommodate, mix and control passage of ingested materials. LÄS MER

  5. 4. The Renin Angiotensin System in the Human Esophageal Mucosa − expression, actions and potential involvement in reflux disease

    Författare :Eleonora Björkman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endoscopic biopsies; epithelial electrical current; epithelial electrical resistance; esophageal mucosae; gastroesophageal reflux disease; mucosal barrier integrity; renin angiotensin system;

    Sammanfattning : The renin angiotensin system (RAS) is a classical endocrine system, regulating body fluid balance and blood circulation. Recent research has shown that the system is being also locally expressed and active in several organs and tissues. LÄS MER

  7. 5. Intestinal permeability : a parameter of mucosal dysfunction

    Författare :Pål Lundin; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Peptide; N-acetylcysteine; Medium-chain glyceride; Mannitol; Macromolecules; Lipid; Kinetics; In vivo; In vitro; In situ; Intestine; Injury; Inflammation; HLA-B27; HCl; Epithelium; Enhancer; dDAVP; 51Cr-EDTA; BSA; Absorption; Albumin; Permeability; Animal physiology; Djurfysiologi;

    Sammanfattning : The gastrointestinal tract has two opposing functions; to absorb nutrients and electrolytes, and to act as a barrier towards hazardous and non-nutritional substances. In the present thesis the barrier function of the gastrointestinal tract was studied in animal models in vivo, in situ and in vitro. LÄS MER