Sökning: "mucoadhesion"

Hittade 5 avhandlingar innehållade ordet mucoadhesion.

  1. 1. Studies on a Novel Powder Formulation for Nasal Drug Delivery

    Författare :Nelly Fransén; Erik Björk; Katarina Edsman; Lars Hovgaard; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nasal drug delivery; nasal powder spray; interactive mixture; mucoadhesion; sodium starch glycolate; superdisintegrant; bioavailability; clinical trial; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : Nasal administration has potential for the treatment of indications requiring a fast onset of effect or for drugs with low oral bioavailability. Liquid nasal sprays are relatively common, but can be associated with suboptimal absorption from the nasal cavity; this thesis shows that nasal absorption can be significantly enhanced with a dry powder formulation. LÄS MER

  3. 2. Polymer Gels as Pharmaceutical Dosage Forms : Rheological Performance and Physicochemical Interactions at the Gel-Mucus Interface for Formulations Intended for Mucosal Drug Delivery

    Författare :Helene Hägerström; Katarina Edsman; Arne Brodin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; gel; rheology; mucoadhesion; mucosal drug delivery; in situ gel; gellan gum; Carbopol; tensile strength; nasal mucosa; intranasal administration; dielectric spectroscopy; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : Drug delivery to the nasal and ocular mucosa faces several obstacles. One of these is from the effective clearance mechanisms present in the nose and eye. Polymer gels with suitable rheological properties can facilitate the absorption of poorly absorbed drugs by increasing the contact time of the drug with the mucosa. LÄS MER

  4. 3. Design of solid dosage forms for mucosal vaccination - Investigations on the influence of excipients on product performance

    Författare :Annika Borde; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; hydrophilic matrix tablets; osmotic pressure; protein release; freeze-drying; Vibrio cholerae; mucoadhesion; Bradford Assay; sublingual vaccine tablet; mucosal vaccination;

    Sammanfattning : Most vaccines today are liquid formulations for parental administration. However, there are several drawbacks connected to these vaccines. Since injectable vaccines only induce systemic antibody responses, they are not effective against the various pathogens that affect mucosal surfaces with poor permeability for serum-derived antibodies, e.g. LÄS MER

  5. 4. Investigating mucin interactions with diverse surfaces for biomedical applications

    Författare :Georgia Petrou; Thomas Crouzier; Anette Larsson; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucus; mucin; protein adsorption; biomaterials; lubrication; mucoadhesion; 4RepCT; Bioteknologi; Biotechnology;

    Sammanfattning : Mucous membranes are covered with mucus, a viscoelastic hydrogel that plays an essential role in their protection from shear and pathogens. The viscoelasticity of mucus is owing to mucins, a group of densely glycosylated proteins. LÄS MER

  7. 5. Interactions of Mucins with Biopolymers and Drug Delivery Particles

    Författare :Olof Svensson; Malmö högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mucin; chitosan; lactoperoxidase; multilayer; mucoadhesion; nanoparticles; ellipsometry;

    Sammanfattning : The main components in the mucous gels apart from water are mucins, which are proteins with high molecular weights and an abundance of negatively charged oligosaccharide side chains. The aim of the investigations was to characterize interactions between mucins and other proteins that are present in the mucous gel, and also between mucins and components used in pharmaceutical formulations. LÄS MER