Sökning: "mouse models"
Visar resultat 1 - 5 av 622 avhandlingar innehållade orden mouse models.
1. Studies of Spinal Motor Control Networks in Genetically Modified Mouse Models
Sammanfattning : Spinal neurons are important in several aspects motor control. For example, the neurons essential for locomotor movements reside in the ventral spinal cord. In this thesis, different motor control functions are being related to neuronal populations defined by their common expression of a gene. LÄS MER
2. Non-invasive ultrasound-based cardiovascular imaging in mouse models of atherosclerosis
Sammanfattning : Atherosclerosis is a chronic multi-factorial vascular disease. It generally requires large clinical settings and over many years to study the disease progression in man. Genetically modified mouse models of atherosclerosis have dramatically increased research feasibility within this area. LÄS MER
3. Microdosimetry of radiohalogens in thyroid models
Sammanfattning : The radiohalogens 123I, 124I, 125I, 131I, and 211At are routinely used or proposed for diagnostic and therapeutic purposes. The different characteristics and application areas of these radioiodine isotopes, together with the possibility to bind them to the same carrier molecule, give many advantages, for example, by enabling relevant biodistribution and dosimetric studies important for dose-planning before radionuclide therapy. LÄS MER
4. Models for the Transfer of Drugs from the Nasal Cavity to the Central Nervous System
Sammanfattning : The blood-brain barrier restricts the access of many compounds, including therapeutic agents, to the brain. Several human studies indicate that nasal administration of hydrophilic compounds, such as peptides, can bypass the blood-brain barrier. The aims of this thesis were to develop and refine models for this direct nose-to-brain transfer. LÄS MER
5. Development of Novel Models for Studying Osteoclasts
Sammanfattning : This thesis focuses on developing and characterizing novel models for studying osteoclasts with an emphasis on how mutations abolishing osteoclastic acidification affect osteoclast signaling and bone remodeling, as well as how to treat patients bearing these rare mutations. Bone remodeling is under normal circumstances a tightly balanced process where resorption of bone by osteoclasts is followed by adequate amounts of bone formation by osteoblasts. LÄS MER