Sökning: "model library design"

Visar resultat 21 - 25 av 62 avhandlingar innehållade orden model library design.

  1. 21. Structural studies and design of Di-iron carboxylate proteins

    Författare :Martin Andersson; Martin Bollinger Jr; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

    Sammanfattning : Di-iron carboxylate proteins perform a wide range of chemical reactions in the cell. These reactions often involve activation of dioxygen to generate highly oxidative species that can be used in catalysis. One member of the di-iron carboxylate family is the enzyme ribonucleotide reductase (RNR). LÄS MER

  3. 22. High-Level Synthesis for SiLago : Advances in Optimization of High-Level Synthesis Tool and Neural Network Algorithms

    Författare :Yu Yang; Ahmed Hemani; Zhonghai Lu; Madhura Purnaprajna; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Electronic Design Automation EDA ; Computer Aided Design CAD ; Algorithm-level Synthesis; SiLago; Optimization Techniques; Neural Network; Informations- och kommunikationsteknik; Information and Communication Technology;

    Sammanfattning : Embedded hardware designs and their automation improve energy and engineering efficiency. However, these two goals are often contradictory. The attempts to improve energy efficiency often come at the cost of engineering efficiency and vice-versa. High-level synthesis (HLS) is a good example of this challenge. LÄS MER

  4. 23. Development and Application of Computational Methods in Antitubercular Drug Design : Identification of Novel Inhibitors of Ribonucleotide Reductase

    Författare :Daniel Muthas; Anders Karlén; Anders Hallberg; Johan Gottfries; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; läkemedelskemi;

    Sammanfattning : Tuberculosis kills approximately 1.7 million people each year around the world making it one of the most lethal infectious diseases. This thesis concerns the development of two computational tools that can support the early stages of drug discovery, and their use in an anti-tubercular drug discovery program. LÄS MER

  5. 24. Engineering Candida antarctica Lipase A for Enantioselective Transformations in Organic Synthesis : Design, Immobilization and Organic Solvent Screening of Smart Enzyme Libraries

    Författare :Ylva Wikmark; Jan-Erling Bäckvall; Romas Kazlauskas; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Candida antarctica Lipase A; protein engineering; enzyme libraries; enzyme immobilization; biocatalysis; organisk kemi; Organic Chemistry;

    Sammanfattning : The use of enzymes as catalysts in organic synthesis constitutes an attractive alternative to conventional chemical catalysis. Enzymes are non-toxic and biodegradable and they can operate under mild reaction conditions. LÄS MER

  7. 25. Expression of a lipase in prokaryote and eukaryote host systems allowing engineering

    Författare :Marianne Wittrup Larsen; Karl Hult; Marina Lotti; KTH; []
    Nyckelord :pseudozzyma candida antarctica lipase B; escherichia coli; pichia pastoris; rational design;

    Sammanfattning : Pseudozyma (Candida) antarctica lipase B (PalB) was expressed in Escherichia coli facilitating protein engineering. The lack of glycosylation was evaluated for a deeper understanding of the difficulties in expressing PalB in E. coli. LÄS MER