Sökning: "mimic"

Visar resultat 1 - 5 av 461 avhandlingar innehållade ordet mimic.

1. 1. Nucleic Acids as Drug Targets - Influence of Platinum Complexes on Duplex Stability and Binding Kinetics

   Författare :Christopher Polonyi; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Anticancer drugs; platinum complexes; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; duplex melting; thermodynamic stability; kinetics; non-coding RNA; miRNA; siRNA; wobble base pair; loop; BRCA1; mimic; luciferase assay;

   Sammanfattning : Gaining a detailed understanding of how human cells are affected by metal-based drugs is crucial, since these drugs have shown great potential in cancer treatment. Cisplatin is used to treat many different types of cancer, e.g. testicular, ovarian, melanoma, bladder, non-small cell lung cancer, small cell lung cancer, myelomas and lymphomas. LÄS MER

3. 2. Design and Synthesis of Novel HIV-1 Protease Inhibitors Comprising a Tertiary Alcohol in the Transition-State Mimic

   Författare :Jenny Ekegren; Anders Hallberg; Daniel Rich; Uppsala universitet; []
   Nyckelord :Chemistry; HIV AIDS; HIV-1 protease inhibitor; transition-state mimic; tertiary alcohol; palladium; cross-coupling; aminocarbonylation; microwave; molybdenum hexacarbonyl; Kemi;

   Sammanfattning : HIV-1 protease inhibitors are important in the most frequently used regimen for the treatment of HIV/AIDS, the highly active antiretroviral therapy (HAART). For patients with access to this treatment, an HIV infection is no longer lethal, but rather a manageable, chronic infection. LÄS MER

4. 3. Mimic: A Microscopic Simulation Model for Rural Road Traffic

   Författare :Stig O. Simonsson; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; computer model; time headway; log normal distribution; Chi-Square test; gap-acceptance; rural road network; car-following; traffic simulation model; alignment; sight distance; Kolmogorov-Smirnoff test; software system; statistics;

   Sammanfattning : The purpose of this dissertation is to outline the theoretical basis of a road traffic simulation model, named Mimic, that constitutes the key elements of a system for estimating road user effects and environmental impacts. The simulation model suggested is a microscopic road traffic simulation model and it is structured to be used for networks of rural roads. LÄS MER

5. 4. Synthetic [FeFe] Hydrogenase Active Site Model Complexes

   Författare :Lennart Schwartz; Sascha Ott; Marcetta Y. Darensbourg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hydrogenase mimic; proton reduction; bioinorganic chemistry; diiron hexacarbonyl complexes; artifical photosynthesis; hydrogen; Organic chemistry; Organisk kemi;

   Sammanfattning : [FeFe]-Hydrogenases (H2ases) are metalloenzymes that can catalyze the reversible reduction of protons to molecular hydrogen as part of the metabolism of certain cyanobacteria and green algae. Due to the low availability of the enzyme, synthetic complexes that mimic the natural active site in structure, function and activity are highly sought after. LÄS MER

7. 5. Lipid Vesicle Fusion: Investigation, Generation and Manipulation of Cell-Membrane Mimics

   Författare :Lisa Simonsson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; diffusion; spreading lipid bilayers; cell mimic; micromanipulation; lipid bilayer; microfluidics; site-specificity; DNA; membrane-receptor interactions; total internal reflection fluorescence microscopy; model system; self-assembly; TIRF microscopy; FRET; exocytosis; vesicles; fluorescence resonance energy transfer; biomembranes; amperometry; membrane fusion;

   Sammanfattning : Membrane fusion is essential for nerve-cell communication, for protein transport between cell organelles and the cell-membrane and for enabling the merger between virus and host membranes during virus infection. In this work, cell-membrane mimics were constructed and evaluated as models for studies of the membrane-fusion process. LÄS MER