Sökning: "microtubule"

Visar resultat 1 - 5 av 71 avhandlingar innehållade ordet microtubule.

  1. 1. Oesophageal Cancer – Novel Targets for Therapy : With focus on Hsp90, EGFR, LRIG, microtubule and telomerase

    Författare :Xuping Wu; Simon Ekman; Johan Lennartsson; Ylva Pausson-Karlsson; Michael Bergqvist; Joachim Gullbo; Stefan Bergstöm; Gunilla Enblad; Claes Mercke; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hsp90; EGFR; LRIG; microtubule; telomerase; oesophageal cancer; imetelstat; DNA double-strand break; 17-AAG; radiation; prognosis; radiosensitisation; microtubule targeting agents; Oncology; Onkologi; Oncology; Onkologi;

    Sammanfattning : Oesophageal cancer is a malignant and aggressive disease with very poor survival. The aim of this thesis was to evaluate novel therapeutic targets in oesophageal cancer. In paper I, Hsp90 was expressed in all 81 oesophageal cancer tissues and also in nine oesophageal cancer cell lines. LÄS MER

  3. 2. Discovery and Characterization of a Novel Microtubule Associated Protein Involved in Cellulose Biosynthesis

    Författare :Alex Selvanayagam Rajangam; Tuula Teeri; Anne-Mie Emons; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MAP; unknown gene; cellulose biosynthesis; Populus; microtubule; DCB; Bioengineering; Bioteknik;

    Sammanfattning : Cell walls are a distinct feature of plants and their chemical constituents, cellulose, hemicelluloses and lignin, are economically valuable. Plant fibres rich in cellulose, which mainly resides in their cell wall, are traditionally used in making paper and textiles. LÄS MER

  4. 3. Regulation of tubulin heterodimer partitioning during interphase and mitosis

    Författare :Per Holmfeldt; Martin Gullberg; Pontus Aspenström; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; microtubule; mitotic spindle; signal transduction; phosphorylation; cancer; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : The microtubule cytoskeleton, which consists of dynamic polymers of alpha/beta tubulin heterodimers, organizes the cytoplasm and is essential for chromosome segregation during mitosis. My thesis addresses the significance and potential interplay between four distinct microtubule-regulatory proteins. LÄS MER

  5. 4. Therapeutic and functional studies in animal models of Alzheimer's disease

    Författare :Astrid Gumucio; Lars Nilsson; Richard Cowburn; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Amyloid-beta; Immunotherapy; IntelliCage; Microtubule; Tau; Alternative splicing; Neuroscience; Neurovetenskap; Medical Cell Biology; Medicinsk cellbiologi; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : Senile plaques (Aβ) and neurofibrillary tangles (tau) are pathological hallmarks of Alzheimer’s disease (AD). If and how the formation of these deposits are mechanistically linked remains mainly unknown. In recent years, the focus has shifted from insoluble protein deposits to soluble aggregates of Aβ and tau. LÄS MER

  7. 5. Three dimensional mathematical modelling of pronuclei migration for the mouse

    Författare :Sofia Tapani; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; fertilisation process; pronucleus; dynamical simulation; SDE; correlation; CUSUM; microtubule; confocal microscopy; dynamical simulation;

    Sammanfattning : The main question addressed in this thesis is what happens between the moment when the sperm enters the egg and the fusion of the male and the female pronuclei. Orientation of the apposing pronuclei most likely plays a decisive role in the polarity of the developing embryo. LÄS MER