Sökning: "mevalonate"
Visar resultat 1 - 5 av 29 avhandlingar innehållade ordet mevalonate.
1. Mevalonate pathway end-products : metabolism, utilization and regulation
Sammanfattning : .... LÄS MER
2. Inhibition of the mevalonate pathway in C. elegans: Consequences and implications
Sammanfattning : The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q (a component of the electron transport chain in mitochondria), dolichols (important for N-linked glycosylation of proteins) and isoprenoids (important for the membrane association of small GTPases). This thesis concerns novel findings about the effect of statin on the mevalonate pathway using C. LÄS MER
3. Following the mevalonate pathway to bone heal alley
Sammanfattning : The mevalonate pathway is an important biosynthetic pathway, found in all cells of virtually all known pro- as well as eukaryotic organisms. This thesis is an investigation into the use of two drugs, originally developed for different applications, but both affecting the mevalonate pathway, in to models of fracture repair. LÄS MER
4. Studies of different secondary metabolites : Natural products from the mevalonate pathway
Sammanfattning : Natural products, also called secondary metabolites, are small molecules that are not involved in main life processes. These can be produced by any living organism and play important roles as chemical weapons, protecting the organism from the competitive environment. LÄS MER
5. Structural and Functional Studies of Peptidyl-prolyl cis-trans isomerase A and 1-deoxy-D-xylulose- 5-phosphate reductoisomerase from Mycobacterium tuberculosis
Sammanfattning : Mycobacterium tuberculosis, the causative pathogen of tuberculosis, currently infects one-third of the world’s population, resulting in two million deaths annually. This clearly shows that tuberculosis is one of the most serious diseases of our times. LÄS MER