Sökning: "methacholine"

Visar resultat 1 - 5 av 31 avhandlingar innehållade ordet methacholine.

  1. 1. Optimizing and evaluation of a methacholine provocation test : with application in occupational research

    Författare :Britt-Marie Sundblad; Bengt-Eric Skoogh; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; Airway responsiveness; methacholine provocation; nitric oxide; eucapnic hyperventilation; organic dust; Fysiologi; Physiology; Fysiologi; Physiology; fysiologi;

    Sammanfattning : We have developed a methacholine provocation method, which detects bronchial responsiveness in more than 80% of healthy subjects. The method enables us to detect differences in bronchial responsiveness within the normal range. With this method FEV1 and Gaw had similar sensitivity in detecting small differences in bronchial responsiveness. LÄS MER

  3. 2. Clinical studies of asthma phenotypes focusing on the role of the leukotrienes

    Författare :Per Gyllfors; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :>asthma; aspirin intolerance; leukotrienes; leukotriene D4 responsiveness; methacholine responsiveness; exhaled nitric oxide;

    Sammanfattning : Inflammation in the airways in connection to asthma is a complex phenomenon and the mechanisms underlying the associated clinical symptoms involve the interaction of many different kinds of cells and mediators, giving rise to different phenotypes. The aim of the present thesis was to investigate the molecular and cellular mechanisms that results in two of these phenotypes, i. LÄS MER

  4. 3. Allergy to laboratory animals : risk factors for development of allergy and methods for measuring airborne rodent allergens

    Författare :Anne Renström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :laboratory animal allergy; atopy; IgE; methacholine provocation; aeroallergen measurement; ELISA; monoclonal antibody; Mus m 1; Rat n 1;

    Sammanfattning : Between 10-50% of workers exposed to laboratory animals, mainly rats or mice, develop laboratory animal allergy (LAA) with symptoms of rhinitis, conjuctivitis, asthma, or urticaria, and IgE against animal allergens. Symptoms often arise within the first years of animal work. Up to half of the symptomatic subjects develop asthma. LÄS MER

  5. 4. Airway responsiveness and exhaled nitric oxide : Studies in asthma and Sjögren's syndrome

    Författare :Dóra Lúðvíksdóttir; Uppsala universitet; []
    Nyckelord :Medical sciences; Airway hyperresponsiveness; nitric oxide; airway inflammation; Sjögren s syndrome; asthma; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : In this thesis, four different types of provocation agents: methacholine, adenosine, cold air and mannitol were used to study different aspects of the airway responsiveness profile in asthma and Sjögren's syndrome. Exhaled nitric oxide (NO) and markers of eosinophil activation, serum eosinophil peroxidase (S-EPO) and eosinophil cationic protein (S-ECP) were measured. LÄS MER

  7. 5. Effects of glucocorticoids or beta 2-agonists on inflammatory responses induced by organic dust in vitro and in vivo

    Författare :Alexandra Ek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Exposure of healthy subjects in a swine barn causes an acute inflammatory response in the airways and an increase in bronchial responsiveness to methacholine. The aim of this thesis was to study the mechanisms by which glucocorticoids or Beta2-agonists interfere with the inflammatory response following swine house dust-exposure both in vitro and in vivo. LÄS MER