Sökning: "metabolic disorders"

Visar resultat 1 - 5 av 204 avhandlingar innehållade orden metabolic disorders.

  1. 1. Hypocortisolism in recurrent affective disorders

    Författare :Martin Maripuu; Karl-Fredrik Norrback; Rolf Adolfsson; Mikael Wikgren; Marie Åsberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affective disorders; Bipolar disorder; Cortisol; Depression; HPA-axis; Hypercortisolism; Hypocortisolism; Lithium; Metabolic syndrome; Obesity; Quality of life; Recurrent depression; Stress; Telomeres;

    Sammanfattning : Bipolar disorders and recurrent depressions are two common psychiatric disorders with a life time prevalence of approximately 1% and 8%, respectively. Despite treatment these patients suffer from affective symptoms up to 50% of the time, resulting in lower well-being. LÄS MER

  3. 2. Metabolic disorders : genes and mechanisms

    Författare :Camilla Maffezzini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mitochondrial disorders constitute a subgroup of the large family of rare monogenic diseases called Inborn Errors of Metabolism (IEM), but defects in mitochondrial activity have also been reported in more common and complex pathologies. In the present thesis, I validate new disease-causing variants and study the underlying molecular defects in three different cases of IEM. LÄS MER

  4. 3. Gut microbiota to counteract metabolic disorders and neuroinflammation : Impact of dietary factors and their potential to prevent Alzheimer’s disease

    Författare :Nittaya Marungruang; Avdelningen för livsmedel och läkemedel; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; gut microbiota; metabolic disorders; inflammation; neuroinflammation; lingonberries; dietary fibre; gut barrier; blood-brain barrier;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia. Increased accumulations of senile plaques and tangles are the known neuropathological hallmarks of AD. However, the exact triggers for such protein accumulations, leading to cognitive impairment and important morphological alteration in AD, are still elusive. LÄS MER

  5. 4. Cardiometabolic risk indicators in bipolar disorders

    Författare :Hemen Najar; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bipolar disorders; Cardiometabolic risk indicators; Cardiovascular diseases;

    Sammanfattning : In addition to disabling mood episodes, bipolar disorders (BDs) predispose individuals to high cardiovascular disease (CVD) risk. This thesis explores the association between BDs and the metabolic risk indicators body mass index (BMI), waist-to-hip ratio (WHR), blood pressure, and lipid profile. LÄS MER

  7. 5. Interference with biological rhythm : a novel approach to metabolic disorders in women

    Författare :Roger Karlsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; GH; cholecystokinin; CCK; osteocalcin; angiotensinogen; diurnal variation; oral contraception; pregnancy; menopause;

    Sammanfattning : Women seem to be largely protected against certain ‘welfare disorders’ such as cardiovacular disease and osteoporosis, during their fertile years.The metabolic changes observed during women’s non-menstrual states, i.e. LÄS MER