Sökning: "meropenem"

Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet meropenem.

  1. 1. Study Design and Dose Regimen Evaluation of Antibiotics based on Pharmacokinetic and Pharmacodynamic Modelling

    Författare :Anders Kristoffersson; Lena Friberg; Mats Karlsson; Pernilla Lagerbäck; Otto Cars; Stephan Schmidt; Uppsala universitet; []
    Nyckelord :pharmacometric; optimal design; pharmacokinetics; pharmacodynamics; PKPD; resistance; antibiotics; modeling; time-kill curve; colistin; meropenem; ciprofloxacin; non-linear mixed effects models; bayesian; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Current excessive use and abuse of antibiotics has resulted in increasing bacterial resistance to common treatment options which is threatening to deprive us of a pillar of modern medicine. In this work methods to optimize the use of existing antibiotics and to help development of new antibiotics were developed and applied. LÄS MER

  3. 2. Pharmacokinetic and Pharmacodynamic Modeling of Antibiotics and Bacterial Drug Resistance

    Författare :Ami Fazlin Syed Mohamed; Lena Friberg; Teresa Dalla Costa; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacokinetics; pharmacodynamics; modeling; antibiotics; resistance; combination; Gram-negative bacteria; gentamicin; colistin; meropenem; newborn infants; critically ill patients; Infectious Diseases; Infektionssjukdomar; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Exposure to antibiotics is an important factor influencing the development of bacterial resistance.  In an era where very few new antibiotics are being developed, a strategy for the development of optimal dosing regimen and combination treatment that reduces the rate of resistance development and overcome existing resistance is of utmost importance. LÄS MER

  4. 3. Antibiotics in patients on chemotherapy; aspects on pharmacokinetic and pharmacodynamic interactions with antineoplastic drugs

    Författare :Anna Nyhlén; Sektion III; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibiotics; neutropenic; antineoplastic agents; pharmacokinetics; pharmacodynamics; PAE; interactions; synergy; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; mykologi; virologi;

    Sammanfattning : The aims of these studies were to investigate the pharmacokinetics of two beta-lactam antibiotics in patients with fever and cytostatic-induced neutropenia and the influence of cytostatic-induced gastrointestinal damage on the absorption of co-trimoxazole. Furthermore to study the pharmacodynamic interactions between antibiotics and antineoplastic drugs and the impact of antineoplastic drugs on the intestinal microflora. LÄS MER

  5. 4. Carbapenem resistance in Pseudomonas aeruginosa

    Författare :Christian Giske; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Carbapenem (imipenem and meropenem) resistance in Pseudomonas aeruginosa is increasing, with global resistance rates approaching 20%. The most common resistance mechanisms are down-regulation of the porin OprD, and increased activity of multi-drug efflux pumps, primarily MexAB-OprM. LÄS MER

  7. 5. Studies on the molecular mechanisms of resistance to fluoroquinolones and carbapenems in selected bacterial species

    Författare :Nagwa Mustafa El Amin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The emergence of mutant bacteria with multi-resistant phenotype, no longer responsive to any of the available therapeutic agents is a growing concern. We have investigated the resistance mechanisms to two classes of antibacterials with broad spectrum of activity, carbapenems and fluoroquinolones. LÄS MER