Sökning: "membrane insertion"

Visar resultat 1 - 5 av 86 avhandlingar innehållade orden membrane insertion.

1. 1. Insane in the membrane: : Insertion of marginally hyrdophobic transmembrane helices and global analysis of membrane protein topology

   Författare :Daniel Nilsson; Arne Elofsson; Susanna Törnroth Horsefield; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

   Sammanfattning : Proteins are responsible for carrying out most of the tasks in a living cell; transcription, translation, replication, movement, catalysis and communication to mention a few. A subset of proteins is the integral membrane proteins, IMPs, which play an important role in governing communication across membranes, whether it is the plasma membrane or an organelle membrane. LÄS MER

3. 2. Into the Membrane and Beyond : Improving Membrane Protein Over-Expression in Escherichia coli

   Författare :Mirjam Klepsch; Jan-Willem de Gier; Reinhard Grisshammer; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; membrane protein over-expression; proteomics; T7 RNA polymerase; peptide transport; strain engineering; Biochemistry; Biokemi; Biophysical chemistry; Biofysikalisk kemi; biokemi; Biochemistry;

   Sammanfattning : Membrane proteins fulfil a wide variety of essential functions in the cell and many are (potential) drug targets. Since their natural abundance is usually very low, most membrane proteins have to be over-expressed for functional and structural studies. LÄS MER

4. 3. Integration and topology of membrane proteins

   Författare :Carolina Boekel; Gunnar von Heijne; IngMarie Nilsson; Stephen High; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; insertion; Sec61; translocation; Biochemistry; Biokemi; biokemi; Biochemistry;

   Sammanfattning : Membrane proteins comprise around 20-30% of most proteomes. They play important roles in most biochemical pathways. All receptors and ion channels are membrane proteins, which make them attractive targets for drug design. Membrane proteins insert and fold co-translationally into the endoplasmic reticular membrane of eukaryotic cells. LÄS MER

5. 4. What’s in? What’s out? And how did it get there? : Studies on topologies and insertion of membrane proteins

   Författare :Marie Österberg; Gunnar von Heijne; Peter Rehling; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; membrane protein; topology; yeast; mitochondria; TIM23; Biochemistry; Biokemi; Biochemistry; biokemi;

   Sammanfattning : Because of their hydrophobic and hydrophilic nature and the need for a lipid bilayer for retaining the native structure, membrane proteins are hard to study. Nevertheless, they are important, as many of our diseases are related to membrane proteins and around 60% of the different pharmaceutical drugs are directed against a membrane proteins [1]. LÄS MER

7. 5. Membrane protein topogenesis

   Författare :Karin Öjemalm; Gunnar von Heijne; Tracy Palmer; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; biokemi;

   Sammanfattning : The membranes of cells are highly complex and heterogeneous structures that fulfill multiple vital tasks. They form thin barriers that seal out the environment, thus defining the cell’s boundaries. LÄS MER