Sökning: "melanocortin peptide"
Visar resultat 6 - 9 av 9 avhandlingar innehållade orden melanocortin peptide.
6. Evolution of Membrane Bound Proteins and their Ligands : The Melanocortin (MC) Receptor Inverse Agonists AgRP2, ASIP2, Drug/Metabolite Transporters, and SPNS1
Sammanfattning : Integral membrane proteins play a key role hormonal and neuronal signaling. Transmembrane helix (TM) proteins form about 27% of the human proteome. Furthermore, 44% of the human drug targets are receptors, and 19% of these are seven-transmembrane domain receptors (GPCRs), which constitute 4% of the entire protein-coding genome. LÄS MER
7. Classification, Evolution, Pharmacology and Structure of G protein-coupled Receptors
Sammanfattning : G protein-coupled receptors (GPCR) are integral membrane proteins with seven α-helices that translate a remarkable diversity of signals into cellular responses. The superfamily of GPCRs is among the largest and most diverse protein families in vertebrates. LÄS MER
8. Tumor recognition by cytotoxic T cells : definition of new tumor antigens and the effect of interleukin-10 on antigen presentation
Sammanfattning : The tumor antigens against which T cell responses have been demonstrated most frequently are not tumor specific but are also expressed on normal tissues. This observation has been interpreted as evidence for breaking of immunological tolerance to normal cellular proteins. LÄS MER
9. Inflammatory proteins in the CNS-relation to Alzheimer's disease
Sammanfattning : Most neurodegenerative disorders are characterised by an inflammatory process in the brain. Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common form of dementia in the elderly. Activated astrocytes and microglia surrounding the amyloid plaques represent evidence for neuroinflammation in the AD brain. LÄS MER