Sökning: "melanocortin peptide"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden melanocortin peptide.

  1. 1. Mutational analysis of melanocortin receptors 1 and 5

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Per-Anders Frändberg; Uppsala universitet.; [1998]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Melanocortin receptor; melanocortin peptide; MSH; NDP-MSH; mutagenesis human phenotype; Farmaceutisk biovetenskap; PHARMACY Biopharmacy; FARMACI Biofarmaci; Pharmaceutics; galenisk farmaci;

    Sammanfattning : The melanocortin receptor family includes five subtypes, named MC1R to MC5R. Melanocortin receptors are predominantly coupled to second messenger pathway of cyclic AMP through coupling to G-protein. This study is focused on structure-function relationship of MC1R and MC5R. LÄS MER

  2. 2. Modelling of melanocortin receptors and their ligands

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Peteris Prusis; Uppsala universitet.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; melanocortin; G-protein coupled receptor; modeling; three-dimensional; QSAR; chemometrics; Farmaceutisk biovetenskap; PHARMACY Biopharmacy; FARMACI Biofarmaci; Pharmaceutical Pharmacology; farmaceutisk farmakologi;

    Sammanfattning : Five subtypes of melanocortin receptors (MC1-MC5R) mediate a wide range of physiological actions, including control of skin tanning, inflammation and food intake. The natural ligands for these receptors are the melanocortins, which are linear peptides 11 to 39 amino acids long. LÄS MER

  3. 3. Brain Stem Involvement in Immune and Aversive Challenge

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Jakob Paues; Linköpings universitet.; Linköpings universitet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipopolysaccharide; Lithium Chloride; anorexia; aversion; parabrachial; brain stem; melanocortin; CGRP; enkephalin; MEDICINE Physiology and pharmacology Physiology Neurobiology; MEDICIN Fysiologi och farmakologi Fysiologi Neurobiologi;

    Sammanfattning : Activation of the immune system by e.g. bacteria induces the acute-phase-response and sickness behaviour. The latter encompasses among other things fever, lethargy, anorexia and hyperalgesia. LÄS MER

  4. 4. Evolution and Pharmacology of Neuropeptide Y Receptors, Implications for vertebrate genome duplications

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Robert Fredriksson; Uppsala universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Evolution; tetraploidizations; G-protein coupled receptor; neuropeptide Y; zebrafish; chicken; rainbow trout; lamprey; genome duplications; peptide YY; pancreatic polypeptide; Neurovetenskap; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Neurology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Neurologi; medicinsk farmakologi; Medical Pharmacology;

    Sammanfattning : The Y receptors comprise a family of evolutionarily related receptors belonging to the superfamily of G-protein coupled receptors (GPCR). Their natural ligands are in mammals neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP). LÄS MER

  5. 5. The Role of the Melanocortin System in Linking Energy Homeostasis with Reward Mechanisms

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Jonas Lindblom; Uppsala universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; PHARMACY Biopharmacy; FARMACI Biofarmaci; Pharmaceutical Pharmacology; farmaceutisk farmakologi;

    Sammanfattning : There is evidence of a link between peripheral signals of energy homeostasis and reward mechanisms. A hypothesis was formulated that the melanocortin (MC) system is part of this link. The hypothesis was tested by a series of receptor expression and neurochemical studies in rats. LÄS MER