Sökning: "megalin"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet megalin.

  1. 1. The megalin receptor

    Författare :Göran Hjälm; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; calcium; parathyroid; gp330; megalin; LRP-2; LDL-receptor super family; endogenous retroviruse; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Ionized calcium is a major player in the living organism. Its importance in both intra- and extracellular mechanisms have been studied in a broad number of publications. LÄS MER

  3. 2. Megalin, an Endocytotic Receptor with Signalling Potential

    Författare :Mårten Larsson; Lars Rask; Bo Åkerström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Megalin; LRP-2; Postsynaptic density-95; Retinol-binding protein; Oligodendrocytes; Central nervous system; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : Megalin is an endocytotic receptor belonging to the low-density lipoprotein family. It has often been viewed only as merely a scavenger receptor of absorptive and secretory epithelia. Recent work has revealed that the megalin intracellular domain contains several motifs potentially binding proteins involved in signal transduction. LÄS MER

  4. 3. Clusterin and Megalin in The Spinal Cord

    Författare :Grzegorz Wicher; Hakan Aldskogius; Lars Hillered; Anders Lewen; Robin Franklin; Uppsala universitet; []
    Nyckelord :Neurosciences; nerve degeneration; hypoglossal nerve; chaperone; apolipoprotein; development; transcription factor; astrocyte; glial differentiation; myelin; cell signalling; Neurovetenskap;

    Sammanfattning : Nerve injury induces up-regulation of the chaperone protein clusterin in affected neurons and adjacent astrocytes but the functional significance of this response is unclear. We find that motor neuron survival is significantly greater in clusterin(+/+) compared to (-/-) mice. LÄS MER

  5. 4. Peptide and non-peptide biomarkers of mortality in patients with advanced chronic kidney disease

    Författare :Jia Sun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Over the last decade, multiple studies have attempted to identify better risk prediction tools specific to the chronic kidney disease (CKD) population. In many cases, these studies have evaluated the use of various peptide biomarkers as prediction tools. LÄS MER

  7. 5. Transcriptional regulation of genes expressed in the parathyroid gland

    Författare :Anders Knutson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : A dynamic interplay between promoter sequences and transcription factors ensures that genes are expressed at appropriate levels in each cell throughout the body. In the present investigation, the promoters of two different genes encoding proteins involved in parathyroid cell function and calcium homeostasis were studied. LÄS MER