Sökning: "mRNA editing"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden mRNA editing.

  1. 1. Regulation of pre-mRNA editing and splicing : the role of the tumour suppressor gene product WT1 in pre-mRNA splicing : coordination of base modification editing by ADAR and pre-mRNA splicing

    Författare :Eva Bratt; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA;

    Sammanfattning : .... LÄS MER

  3. 2. The diverse functions of the ADAR enzymes : Editing and editing-independent effects on gene expression

    Författare :Victor Karlström; Neus Visa; Ayelet Lamm; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA editing; ADAR; Alternative splicing; miRNA processing; neuronal differentiaton; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The adenosine deaminase acting on RNA (ADAR) family of enzymes consists of three members (ADAR1-3). These enzymes are responsible for the deamination of adenosine into inosine in double-stranded RNA, one of the most common RNA modifications in mammals. LÄS MER

  4. 3. Deregulation and editing of microRNAs in metastatic prostate cancer

    Författare :Gjendine Voss; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; bone metastasis; microRNA; RNA editing; A-to-I editing; ADAR; miR-96; miR-379;

    Sammanfattning : Prostate cancer bone metastasis is still not fully understood, and increased knowledge could aid in the development of better treatment options for patients in the future. This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. LÄS MER

  5. 4. Growth hormone and PPARa in the regulation of lipoprotein metabolism

    Författare :Daniel Lindén; Göteborgs universitet; []
    Nyckelord :growth hormone; insulin; fatty acids; PPARa; apolipoprotein B; VLDL; mRNA editing;

    Sammanfattning : In humans, apolipoprotein B (apoB)-100 is produced in the liver and apoB-48 is formed in the intestine. In the rat, however, the two forms of apoB are produced in the liver, leading to the formation of VLDL consisting of either apoB-48 or apoB-100. LÄS MER

  7. 5. Selective ADAR editing and the coordination with splicing

    Författare :Annika Källman; Marie Öhman; Mary O’Connell; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Maturation of precursor messenger RNAs (pre-mRNA) in eukaryotes includes processes like capping, 3’ end formation and splicing. Some premRNAs undergo an additional process called RNA editing where a single nucleotide is modified to generate a new nucleotide identity. LÄS MER