Sökning: "locally advanced"

Visar resultat 1 - 5 av 80 avhandlingar innehållade orden locally advanced.

  1. 1. Aspects of locally advanced colon cancer

    Författare :Emma Rosander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In Sweden, nearly 5000 patients are diagnosed with colon cancer annually and about 20% of these patients have a locally advanced tumor at the time of diagnosis. These tumors are challenging for both surgeons and oncologists and a multimodal treatment strategy is necessary to offer cure. LÄS MER

  3. 2. Optimization of radiotherapy in locally advanced lung cancer

    Författare :Andreas Hallqvist; Göteborgs universitet; []
    Nyckelord :radiotherapy; lung cancer;

    Sammanfattning : Lung cancer is the leading cause of cancer death worldwide as well as in Sweden, where the incidence is around 3500 new cases per year. About 50% have distant metastases by the time of diagnosis and are treated with palliative intent. LÄS MER

  4. 3. Prediction of survival in prostate cancer : aspects on localised, locally advanced and metastatic disease

    Författare :David Robinson; Eberhard Varenhorst; Börje Ljungberg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protstate cancer; oncology; PSA diagnosisk; TNM classification; Oncology; Onkologi;

    Sammanfattning : Background and aims: The clinical course of prostate cancer is highly variable and difficult to predict.Stage at presentation, grade and PSA at diagnosis are traditionally used to predict outcome. The aimof this thesis was to identify strategies for improved survival prediction in men with prostate cancer. LÄS MER

  5. 4. Locally advanced rectal cancer : aspects on management, outcome and quality of life

    Författare :Gabriella Jansson Palmer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Locally recurrent rectal cancer; locally advanced primary rectal cancer; survival; radiological staging; MDT;

    Sammanfattning : Rectal cancer is common in Sweden, with about 1650 patients diagnosed annually. In 10-15% of the patients the tumour is locally advanced at diagnosis, i.e. the cancer is growing outside the mesorectal fascia, into adjacent organs in the pelvis. LÄS MER

  7. 5. Intratumoral CD40 stimulating therapy in patients with advanced cancer

    Författare :Sandra Irenaeus; Gustav Ullenhag; Angelica S. Loskog; Poulam Patel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40; CD40L; immunotherapy; early clinical studies; advanced cancer; intratumoral administration; Medicinsk vetenskap; Medical Science; Oncology; Onkologi;

    Sammanfattning : CD40-CD40L interaction activates DCs to become highly efficient APCs and skews the adaptive immune response towards a Th I phenotype driving cytotoxic T cells, M1 macrophages and natural killer cells. Furthermore, engagement of CD40L to CD40 positive cancer cells can have direct anti-proliferative effects, induce apoptosis and increase expression of MHC and other co-stimulatory molecules, thereby enhancing cancer cell recognition. LÄS MER