Sökning: "lipotoxicity"
Visar resultat 1 - 5 av 21 avhandlingar innehållade ordet lipotoxicity.
1. Search for molecular and metabolic mechanisms contributing to impaired β-cell function
Sammanfattning : Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. LÄS MER
2. Hormone-Sensitive Lipase and the Pancreatic Beta-Cell
Sammanfattning : Hormone-sensitive lipase (HSL) is a key enzyme in fatty acid mobilization. It is acutely regulated by extracellular signals via reversible phosphorylation. In the recent past, the focus of type 2 diabetes research has moved towards the lipid component. LÄS MER
3. Perilipin expression in the islets of Langerhans and Surface expression in the baculovirus/insect cell system
Sammanfattning : Surface display in insect cells: Systems available for surface display that utilize bacterial phages are insufficient for displaying a number of eukaryotic proteins. By instead presenting proteins on the surface of eukaryotic cells or virus, some of these problems might be overcome. LÄS MER
4. Effects of Free Fatty Acids on Insulin and Glucagon Secretion : – with special emphasis on the role of Free fatty acid receptor 1
Sammanfattning : Prevalence of type 2 diabetes mellitus (T2DM) is still rising and even so in the juvenile population. Obesity is highly associated with increased risk for developing T2DM. LÄS MER
5. Cell Membrane Homeostasis in Mammals - The roles of ADIPOR2 and TLCD1 & 2
Sammanfattning : Ten nanometers. That is the approximate thickness of the plasma membrane that separates the extracellular space from the entire cellular machinery. An asymmetrical bilayer consisting of predominantly phospholipids in which proteins and carbohydrates are anchored and exert their function. LÄS MER