Sökning: "lipid-protein interactions"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden lipid-protein interactions.
1. Membrane-mimetic systems : Novel methods and results from studies of respiratory enzymes
Sammanfattning : The processes localized to biological membranes are of great interest, both from a scientific and pharmaceutical point of view. Understanding aspects such as the detailed mechanism and regulation of these processes requires investigation of the structure and function of the membrane-bound proteins in which they take place. LÄS MER
2. Determining Ligand- and Lipid- Interactions of SLC Transporters
Sammanfattning : Solute carrier transporters (SLCs) mediate the inter- and intra- cellular trafficking of a plethora of substrates and are essential to cell homeostasis. Despite their importance to human physiology and their potential as therapeutic targets, many SLCs are considered orphans as the physiological substrate has not been experimentally determined. LÄS MER
3. Advanced computations and mass-spectrometric techniques to unravel the dynamics and interactions of proteins
Sammanfattning : Proteins are an important class of biomolecules, involved in the metabolism, regulation, structure and transport in cells. Unfortunately, many diseases are caused by protein dysfunction. When proteins perform their normal function, they may interact with each other or change their conformation. LÄS MER
4. Detection of Lipids and Proteins on Biological Surfaces using Imaging Mass Spectrometry
Sammanfattning : Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a technique that can be used for imaging the spatial distribution of many different molecules at the same time. It is very sensitive for detection of small biomolecules, such as lipids, whereas larger biomolecules, such as peptides and proteins, cannot be detected as intact entities due to fragmentation. LÄS MER
5. Unravelling the structure and dynamics of lipid nanoparticles for biomolecule delivery
Sammanfattning : Encapsulation in self-assembled lipid structures has been shown to increase the stability of large biomolecules, including proteins and nucleic acids (NAs), which has many potential applications in the food and pharmaceutical industries. In order to fully optimise the encapsulation system for a certain application, however, it is important to understand the effect of the encapsulated biomolecule on the lipid structure and vice versa. LÄS MER
