Sökning: "linkage studies"

Visar resultat 1 - 5 av 375 avhandlingar innehållade orden linkage studies.

  1. 1. Genetic aspects of stroke : association and linkage studies in a northern Swedish population

    Författare :Per-Gunnar Wiklund; Birgitta Stegmayr; Kjell Asplund; Dan Holmberg; Alun Evans; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Internal medicine; stroke; genetics; polymorphism; association; linkage; risk factors; plasminogen activator inhibitor-1; tissue plasminogen activator; angiotensin converting enzyme; angiotensin II receptor type 1; phosphodiesterase 4D; Invärtesmedicin; Internal medicine; Invärtesmedicin; medicin; Medicine;

    Sammanfattning : Stroke is a common, multifactorial cardiovascular disease. A stroke event is the result of traditional risk factors (i.e. hypertension, diabetes, smoking), environmental exposures and genetic factors in a complex interplay. LÄS MER

  3. 2. Diagnostic Evaluation of Schizophrenia for Genetic Studies

    Författare :Birgit Ekholm; Rolf Adolfsson; Erik Jönsson; Göran Sedvall; Leif Lindström; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psychiatry; Schizophrenia; Diagnostic evaluation; Molecular genetic studies; Linkage; Association; Psykiatri; Psychiatry; Psykiatri; psykiatri; Psychiatry;

    Sammanfattning : Schizophrenia is one of the most severe mental disorders. Heredity is accepted as a major causative factor. To find molecular mechanisms behind schizophrenia, patient materials with reliable and valid diagnoses must be identified. LÄS MER

  4. 3. Genetic studies in rheumatoid arthritis : familial studies and analysis of relationships to atherothrombotic comorbidity

    Författare :Lisbeth Ärlestig; Solbritt Rantapää Dahlqvist; Dan Holmberg; Åsa Torinsson Naluai; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; genetics; familial studies; ACPA and cardiovascular co-morbidity; reumatologi; rheumatology; genetik; Genetics; cardiovascular disease; hjärt- och kärlforskning;

    Sammanfattning : Background. Rheumatoid arthritis (RA) is an autoimmune disease mainly affecting the joints but has also extra articular manifestations and an increased cardiovascular (CV) co-morbidity. Rheumatoid factor (RF) and antibodies against citrullinated proteins/peptides (ACPA) are diagnostically important and are related to a more severe disease. LÄS MER

  5. 4. Genetic Studies of Alzheimer's Disease

    Författare :Elin Blom; Anna Glaser; Martin Ingelsson; Lars Lannfelt; Jan Hillert; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Linkage; Affected sib-pairs; APOE; APP duplication; 10q21; 19q13; Wnt signaling; Geriatrics and medical gerontology; Geriatrik och medicinsk gerontologi;

    Sammanfattning : Patients with Alzheimer's disease (AD) often have a family history of the disease, implicating genetics as a major risk factor. Three genes are currently known to cause familial early-onset AD (65 years), only the APOE gene has repeatedly been associated to AD, where the ε4 allele increases disease risk and decreases age at onset. LÄS MER

  7. 5. Genetic studies on Systemic Lupus Erythematosus : A fine mapping and candidate gene approach

    Författare :Veronica Magnusson; Jerry Lanchbury; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Systemic Lupus Erythematosus; complex disease; linkage analysis; candidate gene; association studies; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

    Sammanfattning : Linkage in the 2q37 region was evaluated using microsatellite markers in multi-case families from Sweden, Iceland and Norway. Both the two-point and the multipoint linkage analysis show highly significant LOD scores (Z=4.51 and 6.03, respectively). LÄS MER