Sökning: "invärtesmedicin Invärtesmedicin Endokrinologi"
Visar resultat 1 - 5 av 15 avhandlingar innehållade orden invärtesmedicin Invärtesmedicin Endokrinologi.
1. Fibroblast growth factor-23 and Klotho in bone/mineral and parathyroid disorders
Sammanfattning : Fibroblast growth factor-23 (FGF23) is a novel, bone-produced hormone that regulates renal phosphate (Pi) reabsorption and calcitriol metabolism. Disorders of mineral and bone metabolism, such as autosomal dominant hypophosphatemic rickets (ADHR) and hyperostosis-hyperphosphatemia syndrome (HHS), witness the importance of well-balanced serum levels of FGF23. LÄS MER
2. Diagnosing hyper- and hypocortisolism using saliva samples : pitfalls and how to avoid them
Sammanfattning : Background: Cushing's syndrome (CS) is caused by high cortisol secretion whereas insufficient cortisol secretion is called adrenal insufficiency (AI). Both are rare diseases with substantial diagnostic delay, and high morbidity and mortality even though effective treatment is available. LÄS MER
3. Brain function and glucocorticoids in obesity and type 2 diabetes including effects of lifestyle interventions
Sammanfattning : Background Obesity and associated metabolic dysregulation are linked to impaired cognitive function and alterations in brain structure, which increases the risk of age-related dementia. Increased glucocorticoid (GC) exposure may be a potential mediator of these negative effects on the brain. LÄS MER
4. Inhibition of 11 ß-HSD. Hemodynamic and hormonal response induced by liquorice
Sammanfattning : Introduction: The enzyme 11 ß-hydroxysteroid-dehydrogenas (11 ß-HSD) type 2 that converts the active hormone cortisol to the inactive cortisone is inhibited by glycyrrhetinic acid (GA), the active substance in liquorice. This leads to hypertension, hypokalaemia and sodium- and fluid retention, the syndrome of pseudo-hyperaldosteronism. LÄS MER
5. Insulin-like Growth Factor-I (IGF-I) and Interleukin-6 (IL-6) regulate body fat
Sammanfattning : The aim of this thesis was to investigate the role of insulin-like growth factor-I (IGF-I) and interleukin-6 (IL-6) in the regulation of metabolism and body fat mass. Circulating IGF-I is mainly liver derived, while a large part of circulating IL-6 is produced by adipose tissue. LÄS MER