Sökning: "intracellular swelling and -shrinkage"
Visar resultat 1 - 5 av 14 avhandlingar innehållade orden intracellular swelling and -shrinkage.
1. High-resolution Imaging of Cleared and Expanded Kidney Tissue Samples
Sammanfattning : The kidney is one of the most important and complex organs in the humanbody with the task of filtering hundreds of litres of blood daily. It is responsiblefor the salt and acid/base balance in the body, as well as secretinghormones important for red blood cell production and blood pressure regulation. LÄS MER
2. Roles of unconventional ion channels and insulin granule structure in the pathogenesis of type-2 diabetes
Sammanfattning : T2D is the most widespread endocrine disease. In conventional stimulus secretion coupling increased blood glucose is metabolized causing an increased intracellular level of ATP and closure of the KATP channels, and this, in turn, depolarizes the cell membrane leading to the opening of voltage-gated Ca2+ channels, the influx of Ca2+ and exocytosis of insulin granules. LÄS MER
3. Environmental input to the pancreatic β-cells - the role of mechanosensitive and other ion channels
Sammanfattning : Compound input from genetic predisposition, environmental factors and lifestyle lead to beta-cell dysfunction which initiates the development of type 2 diabetes. Understanding the linkage between the environmental input and gene regulatory pathways controlling beta-cell function is key for developing novel therapies against T2D. LÄS MER
4. Genetics of systemic autoimmunity and comorbidities
Sammanfattning : Sjögren‘s syndrome (SS) is a systemic autoimmune disease that typically affects the salivary and lacrimal glands leading to dry eyes and dry mouth, but the patients may also have systemic involvement. Most patients with SS carry autoantibodies, most often to the Ro (SSA) and La (SSB) proteins. LÄS MER
5. Chloride Channels and Brown Fat Cells
Sammanfattning : Chloride ion channels are macromolecular pores providing for passage of chloride ions (and certain other inorganic and organic anions) through the cell membrane, down their electrochemical gradients. Chloride channels are differentially expressed in various cells, to best suit specific cellular activities. LÄS MER