Sökning: "interstitial insulin"

Visar resultat 1 - 5 av 23 avhandlingar innehållade orden interstitial insulin.

1. 1. Insulin resistance in skeletal muscle. With special reference to interstitial insulin and glycerol

   Författare :Mikaela Sjöstrand; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin resistance; skeletal muscle; microdialysis; interstitial insulin; interstitial glycerol;

   Sammanfattning : Insulin resistance is a central feature of type 2 diabetes and obesity and is associated with cardiovascular disease. In insulin-resistant muscle, the insulin-mediated glucose uptake is decreased.The delivery of insulin to the interstitial fluid of human skeletal muscle has previously not been investigated. LÄS MER

3. 2. The regulation of muscle interstitial insulin, nutrients and blood flow in insulin resistant models. An investigation using the euglycemic insulin clamp and microdialysis techniques

   Författare :Maria Niklasson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin resistance; skeletal muscle; glucose uptake; transcapillary transport; interstitial fluid; euglycemic insulinclamp; microdialysis; blood flow; vasodilation;

   Sammanfattning : Insulin resistance, mainly located to the skeletal muscle tissue, is one prominent feature in thedevelopment of non insulin-dependent diabetes mellitus (NIDDM) and further, associated withcardiovascular diseases. In this context the importance of blood flow for insulin sensitivity has beensuggested by regulating the delivery of insulin and nutrients to the target cells. LÄS MER

4. 3. Interleukin-6 as a mediator of insulin resistance

   Författare :Victoria Rotter Sopasakis; Göteborgs universitet; []
   Nyckelord :;

   Sammanfattning : A potential role of interleukin (IL)-6 for the metabolic abnormalities seen in obesity and insulinresistance was postulated when it was discovered that circulating IL-6 levels were elevated in obeseand insulin-resistant as well as type 2 diabetic individuals. Later it was shown that the adipose tissuewas a major site of IL-6 production, accounting for 15-35% of the total circulating levels. LÄS MER

5. 4. Insulin and growth hormone : regulation of adipocyte metabolism during infancy and childhood

   Författare :Ashraf Fawzy Kamel; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :human; rat; development; adipocytes; lipolysis; lipogenesis; glucose transport GLUT1; GLUT4; insulin; insulin receptor; growth hormone; growth hormone receptor microdialysis; obesity; Prader-Willi syndrome;

   Sammanfattning : The aim of the present investigation was to investigate the role of insulin and growth (GH) in adipose tissue metabolism during development. Lipolysis and lipogenesis were studied in isolated adipocytes from humans and rats of various ages. LÄS MER

7. 5. Studies of the adipose tissue in insulin resistance with microdialysis

   Författare :Madelene Sandqvist; Göteborgs universitet; []
   Nyckelord :;

   Sammanfattning : Type 2 diabetes is characterized by a combination of insulin resistance and an impaired insulin secretion. Theprevalence of the disease has taken epidemic proportions, and it is therefore of great concern to characterize itspathophysiology, as well as to identify individuals with increased risk for the disease, enabling to take measuresfor prevention and cure. LÄS MER