Sökning: "infusion reaction"

Visar resultat 1 - 5 av 28 avhandlingar innehållade orden infusion reaction.

  1. 1. Treatment of arthritis with tumour necrosis factor antagonists. Clinical, immunological and biochemical aspects

    Författare :Meliha C Kapetanovic; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skelett; muskelsystem; reumatologi; Skeleton; muscle system; rheumatology locomotion; ANA; infusion reaction; influenza vaccination; pneumococcal vaccination; COMP; TNF antagonists; spondylarthropathies; arthritis; rheumatoid arthritis;

    Sammanfattning : Abstract The treatment of arthritis has undergone a dramatic change since biological agents targeting specific mediators of the disease process have been introduced. Tumour necrosis factor (TNF) antagonists have been shown to reduce signs and symptoms of disease and to retard the development of tissue damage in the majority of patients. LÄS MER

  3. 2. Neurobiological basis of the nicotine withdrawal reaction : an experimental analysis

    Författare :Bengt E Hildebrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :rat; nicotine; nicotine withdrawal; behavior; locomotor activity; microdialysis; intracerebral injections; mesolimbocortical; dopamine; ventral tegmental area; nucleus accumbens; amygdala; immediate-early genes; c-fos;

    Sammanfattning : The mesolimbocortical dopamine (DA) system is pivotal for the mediation of the reinforcing effects of many dependence-producing drugs. It consists of cell bodies in the ventral tegmental area (VTA) that project to e.g. the nucleus accumbens (NAC), the central nucleus of amygdala (CNA) and the medial prefrontal cortex. LÄS MER

  4. 3. Mechanisms and Therapeutic Interventions of Instant Blood-Mediated Inflammatory Reaction (IBMIR)

    Författare :Helena Johansson; Bo Nilsson; Olle Korsgren; Kristina Nilsson-Ekdahl; Tomas Lindahl; Uppsala universitet; []
    Nyckelord :Immunology; Diabetes; Islet transplantation; Islets of Langerhans; Coagulation activation; Complement activation; IBMIR; Tissue factor; Low molecular weight dextran sulfate; Immunologi;

    Sammanfattning : Intraportal transplantation of isolated islets of Langerhans is a procedure approaching clinical acceptance as a treatment for patients with type I diabetes mellitus. One major problem with this treatment is that large amounts of cells are lost at the time of infusion into the portal vein, resulting in a low level of engraftment of the islets. LÄS MER

  5. 4. Allergen-induced late airways reaction in the pig : influence of endogenous and exogenous glucocorticoids

    Författare :Cecilia Fornhem; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ascaris suum; bronchial circulation; bronchial provocation test; budesonidecortisol; leukotrienes; eosinophil peroxidase; eosinophils; histamine; immunohistochemistry; metyrapone; minipig; myeloperoxidase; neutrophils; pig.;

    Sammanfattning : A novel model for studies of the allergen-induced late reaction in the lower airways was developed in the pig. The influence on late bronchial obstruction and granulocyte function of endogenous cortisol levels and treatment with the glucocorticoid budesonide (BUD) was evaluated. LÄS MER

  7. 5. Engineering more efficient multipotent mesenchymal stromal (stem) cells for systemic delivery as cellular therapy

    Författare :Guido Moll; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :multipotent mesenchymal stromal stem cell;

    Sammanfattning : Do mesenchymal progenitor cells naturally circulate in vivo? Are they fundamentally compatible with blood? What mechanism allows them to be in contact with blood? How do we make therapeutic cells with blood-compatible properties? Can we optimise their survival and therapeutic function upon systemic delivery? How should we best isolate and condition therapeutic multipotent mesenchymal stromal (stem) cells (MSCs) before infusion, to achieve an optimum and sustainable clinical response in patients? This thesis covers many aspects related to these questions. It describes how MSCs interact with the instant blood-mediated inflammatory reaction (IBMIR) upon infusion. LÄS MER