Sökning: "individual case safety reports"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden individual case safety reports.
1. Drug interaction surveillance using individual case safety reports
Sammanfattning : Background: Drug interactions resulting in adverse drug reactions (ADRs) represent a major health problem both for individuals and society in general. Post-marketing pharmacovigilance reporting databases with compiled individual case safety reports (ICSRs) have been shown to be particularly useful in the detection of novel drug - ADR combinations, though these reports have not been fully used to detect adverse drug interactions. LÄS MER
2. Safety of Medication in Paediatrics
Sammanfattning : Background: In paediatrics, the limited documentation to guide medication, the lack of suitable dosage forms, and the continuous development in childhood present a scenario where safety of medication is a particular challenge.Aim: To explore reported adverse drug reactions (ADRs) and the challenges in prescribing and administering medicines in paediatrics, in order to identify and suggest areas needing international surveillance within medication safety and improvement in the clinical setting. LÄS MER
3. Systems Dependability Engineering for Wind Power Applications : Challenges, Concepts, and System-Level Methodologies
Sammanfattning : Complexity and uncertainty have impacted wind power systems and their applications.Commercial wind power asset exhibits complex system behaviour due tostochastic loading characteristics of its installation context. However, differentstakeholders’ practices in whole life cycle processes try to treat multi-disciplinarycomplexity issues. LÄS MER
4. The potential of ambulance records for a road traffic safety agenda in low-income cities : studies from Karachi, Pakistan
Sammanfattning : Road traffic injuries (RTIs) are a major public health problem in low-income countries. The overall aim of the thesis is to increase knowledge about the characteristics of RTI events and victims and their changes over time in an urban, low-income setting. The accuracy of ambulance data for RTI surveillance is also investigated. LÄS MER
5. Statistical methods for knowledge discovery in adverse drug reaction surveillance
Sammanfattning : Collections of individual case safety reports are the main resource for early discovery of unknown adverse reactions to drugs once they have been introduced to the general public. The data sets involved are complex and based on voluntary submission of reports, but contain pieces of very important information. LÄS MER