Sökning: "immunoglobulin G IgG"

Visar resultat 1 - 5 av 40 avhandlingar innehållade orden immunoglobulin G IgG.

  1. 1. Clinical and immunological aspects of IgG subclass deficiency : Predictors for the need of immunoglobulin replacement therapy

    Författare :Per Wågström; Charlotte Dahle; Sofia N. Nyström; Åsa Nilsdotter-Augustinsson; Mats Nilsson; Ola Winqvist; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunoglobulin G subclass deficiency; inflammation; lymphocytes; fatigue; co-morbidity; immunoglobulin G replacement therapy;

    Sammanfattning : Background: Predominantly antibody deficiencies (PAD) are inborn errors of immunity, and associate with increased susceptibility to infections. Life-long immunoglobulin replacement therapy (IgRT) is introduced based on Ig-levels and the frequencies and severity of infections. LÄS MER

  3. 2. Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

    Författare :Liang Zhang; Véronique Chotteau; Michael J. Betenbaugh; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chinese hamster ovary cells; glycosylation; IgG; mathematical modelling; experimental design; perfusion; carbon sources; GReBA; Bayesian network; probabilistic graphic model; Bioteknologi; Biotechnology;

    Sammanfattning : Chinese hamster ovary (CHO) cells are the most popular expression system for the production of biopharmaceuticals. More than 80% of the approved monoclonal antibodies (mAbs) or immunoglobulin G (IgG) are produced with these cells. Glycosylation is a usual post- translational modification important for therapeutic mAbs. LÄS MER

  4. 3. Exploitation of interactions with the neonatal Fc receptor to manipulate biological half-lives for therapeutic applications

    Författare :Shengze Yu; Torbjörn Gräslund; Mats Ohlin; KTH; []
    Nyckelord :Glioblastoma Multiforme GBM ; Prolacin Prl ; Prolacin receptor PrlR ; Prolactin antagonist PrlRA ; Albumin binding domain ABD ; serum albumin SA ; half-life extension; FcRn; Affibody; human growth hormone hGH ; immunoglobulin G IgG ; blocking; autoimmune disease; Bioteknologi; Biotechnology;

    Sammanfattning : Protein engineering provides powerful tools to create useful proteins with desired properties. In this thesis, rational design principles have been used for development of fusion proteins that can interact with the neonatal Fc receptor (FcRn) for potential medical applications. FcRn is widely expressed in the human body. LÄS MER

  5. 4. Analysis of proteins related toautoimmune and inflammatorydiseases with focus on newenrichment methodologies and MALDI-TOF MS

    Författare :Yuye Zhou; Åsa Emmer; Margret Thorsteinsdottir; KTH; []
    Nyckelord :Protein; Glycopeptide; IgG; Osteopontin; Enrichment; Digestion; Separation; Microchip; MALDI-TOF MS; Kemi; Chemistry;

    Sammanfattning : Proteins have been widely studied in biological sample analysis due to the association with diseases. In the present project, method and technique development was carried out on the analysis of two proteins, immunoglobulin G (IgG) and osteopontin (OPN). LÄS MER

  7. 5. Evolutionary and functional studies of protein H: a surface molecule of Streptococcus pyogenes

    Författare :Inga-Maria Frick; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intracellular transportation; adhesion; aggregation; FNIII domain; albumin-binding; M-like protein; convergent evolution; protein G; Streptococcus pyogenes; IgG-binding; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Several bacterial species express surface proteins with affinity for the Fc part of human IgG. This thesis describes evolutionary and functional studies of protein H, an IgGFc-binding surface protein of the human pathogen Streptococcus pyogenes. LÄS MER