Sökning: "immunogenicity"

Visar resultat 1 - 5 av 144 avhandlingar innehållade ordet immunogenicity.

1. 1. Development of immunogenicity models in mice for improved risk assessment of biopharmaceuticals

   Författare :Britta Granath; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anti-drug antibodies; immunogenicity; biopharmaceuticals; immunoglobulin; 3R;

   Sammanfattning : The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins including monoclonal antibodies (mAb) can lead to adverse events and clinical complications. These include reduced effect of the drug and autoimmune conditions if the administered drug is analogous to endogenous proteins. LÄS MER

3. 2. Pharmacometric Modeling in Rheumatoid Arthritis

   Författare :Brigitte Lacroix; Lena Friberg; Mats Karlsson; Maria Laura Sargentini-Maier; Kosmas Kretsos; Ekaterina Gibiansky; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; PKPD; immunogenicity; ACR; IPPSE; certolizumab pegol;

   Sammanfattning : Biologic therapies have revolutionized the treatment of rheumatoid arthritis, a common chronic inflammatory disease, mainly characterized by the chronic inflammation of the joints. The activity and progression of the disease are highly variable, both between subjects and between the successive assessments for the same subject. LÄS MER

4. 3. Characterization of antibody specificity using peptide array technologies

   Författare :Björn Forsström; Mathias Uhlén; Markus Templin; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibody; Epitope mapping; Peptide array; Suspension bead array; Antigen; Specificity; Cross-reactivity; Immunization; Immunogenicity; Bioteknologi; Biotechnology;

   Sammanfattning : Antibodies play an important role in the natural immune response to invading pathogens. The strong and specific binding to their antigens also make them indispensable tools for research, diagnostics and therapy. LÄS MER

5. 4. Development of novel vaccine strains of Vibrio cholerae and studies on the role of serotype in epidemic spread of cholera

   Författare :Stefan Karlsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cholera; Vibrio cholerae; Serotype; Ogawa; Inaba; Hikojima; Vaccine; Immunogenicity; serotype switching; wbeT;

   Sammanfattning : Cholera, caused by bacterium Vibrio cholerae O1, is a severe diarrheal disease with an estimated 3-5 million cases and more than 140 000 deaths every year particularly affecting children under 5 years of age. It can be found all over the world and often causes cholera in places where access to clean water or proper sanitary facilities are limited or compromised. LÄS MER

7. 5. Methods for Generation and Characterization of Monospecific Antibodies

   Författare :Johan Rockberg; Mathias Uhlén; John McCafferty; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; antibody; epitope mapping; HER2; human protein atlas; immunogenicity; proteomics; Bioengineering; Bioteknik;

   Sammanfattning : Recent advances in biotechnology have generated possibilities to investigate and measure parts of life previously left for believers to explain. Utilizing the same book of recipes, the genome, our cells produce selections of proteins at a time and thereby niche into a multitude of specialized cell types, tissues and organs comprising our body. LÄS MER