Sökning: "iPS cells"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden iPS cells.

  1. 1. Integration and function of new neurons generated from fibroblasts and adult neural stem cells in the pathological brain

    Författare :James Wood; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurogenesis; neural stem cells; iNs; iPS cells; stroke; epilepsy; electrophysiology;

    Sammanfattning : In Papers One through Six we have investigated the function and integration of “new” neurons – new neurons born from neural stem cells in the adult brain, and new neurons in the sense that they were generated from fibroblasts. Papers One and Two focused on the new neurons generated from neural stem cells in the SVZ and SGZ after pathological insults. LÄS MER

  3. 2. Chemogenetics, Induced Neurons and Pluripotent Stem Cells: Towards Advanced Gene and Cell Therapies Targeting Epilepsy

    Författare :Natalia Avaliani; Epilepsicentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chemogenetics; iPS; iN; electrophysiology; gene and cell therapy; Epilepsy;

    Sammanfattning : The complexity of the central nervous system and existence of the blood-brain barrier often causes difficulties for traditional pharmacological treatments of neurological diseases. This thesis explores the feasibility and potential for novel gene and cell therapy approaches, which hold better promise for neurological disorders, while particularly targeting epilepsy. LÄS MER

  4. 3. Manipulating neural stem cells

    Författare :Malin Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The stem cell field is a fairly young but fast growing scientific field. Our understanding of stem cells has changed tremendously over the last couple of decades. This in mainly due to the development of new techniques that has enabled us to study stem cells from a completely new perspective. LÄS MER

  5. 4. Single cell analysis of iPS derived neural stem cells and neurons

    Författare :Matti Lam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In vitro derived neural stem cells can be used to model events of neurogenesis and neurodevelopmental dysfunction. Formation of stable neural stem cell environments relies on cellular components to stabilize cell-to-cell connections. LÄS MER

  7. 5. Human induced pluripotent stem cells in regenerative medicine

    Författare :Elias Uhlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human induced pluripotent (iPS) cells offer a theoretically inexhaustible cell source for the derivation of any cell type and are a promising tool in regenerative medicine. Cells can be derived from the recipients own tissue or from pre-selected HLA-matched donors. LÄS MER