Sökning: "human Rad51"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden human Rad51.
1. Expression and regulation of Rad51 in human cells
Sammanfattning : Double strand breaks (DSBs) can be caused by exogenous DNA damaging agents or by endogenous processes, and may lead to chromosomal breakage and rearrangement resulting in apoptosis or tumorigenesis. The repair of DSBs in higher eukaryotes is to a large extent accomplished by homologous recombination (HR), a process in which DNA from a complementary strand is used as a template for repair synthesis. LÄS MER
2. Unveiling Mechanistic Details of Macromolecular Interactions: Structural Design and Molecular Modelling of DNA-Protein Systems in Their Active State
Sammanfattning : Molecular structure is fundamental for understanding mechanisms of molecular interactions. This applies not least to understanding biological function: every biological cell, whether bacterial or human, is an immensely complex system of thousands of molecules that exist in constant motion and interaction with each other. LÄS MER
3. Aspects of DNA Strand Exchange: Recombination Proteins and Model System Studies
Sammanfattning : DNA recombination is of fundamental importance to all living cells; it is part of the DNA repair machinery and a means to generate genetic diversity. DNA strand exchange, the exchange of strands between homologous DNA molecules, is the central reaction of the recombination process. LÄS MER
4. Identification of novel BRCA2-binding proteins that are essential for meiotic homologous recombination
Sammanfattning : Meiotic recombination is a molecular process in which the induction and repair of programmed DNA double-strand breaks (DSBs) creates genetic exchange between homologous chromosomes and thus increases genetic diversity and ensures chromosome segregation. Breast cancer susceptibility gene 2 (BRCA2) is a potent cancer suppressor and is required for DSB repair by homologous recombination (HR) in mitosis. LÄS MER
5. The maintenance of telomeres in the budding yeast Naumovozyma castellii
Sammanfattning : Linear chromosomes of eukaryotic cells require the presence of functional nucleoprotein terminal structures, known as telomeres, to protect the integrity of the genome. The telomere is a highly dynamic and regulated structure constituted by short tandem DNA repeats rich in guanine nucleotides that extent as double-stranded DNA ending in a single-stranded 3′ overhang. LÄS MER
