Sökning: "homology search"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden homology search.

  1. 1. The relationship between orthology, protein domain architecture and protein function

    Författare :Kristoffer Forslund; Erik Sonnhammer; Cristina Al-Khalili Szigyarto; Sarah Teichmann; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; homology; orthology; paralogy; gene duplications; protein function prediction; low-complexity regions; protein domains; domain architecture evolution; introns; intron position conservation; orthology conjecture; domain grammar hypothesis; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

    Sammanfattning : Lacking experimental data, protein function is often predicted from evolutionary and protein structure theory. Under the 'domain grammar' hypothesis the function of a protein follows from the domains it encodes. LÄS MER

  3. 2. A Study in RNA Bioinformatics : Identification, Prediction and Analysis

    Författare :Eva Freyhult; David Ardell; Robert Giegerich; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA; bioinformatics; secondary structure; structure prediction; dynamic programming; energy landscape; homology search; sequence logo; tRNA; Bioinformatics; Bioinformatik;

    Sammanfattning : Research in the last few decades has revealed the great capacity of the RNA molecule. RNA, which previously was assumed to play a main role only as an intermediate in the translation of genes to proteins, is today known to play many important roles in the cell in addition to that as a messenger RNA and transfer RNA, including the ability to catalyze reactions and gene regulations at various levels. LÄS MER

  4. 3. Bacterial DNA repair and molecular search

    Författare :Arvid H. Gynnå; Johan Elf; Stephen Kowalczykowski; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA repair; DNA damage; homologous recombination; homologous repair; recombination; RecA; I-SceI; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : Surveillance and repair of DNA damage is necessary in all kinds of life. Different types of DNA damage require different repair mechanisms, but these mechanisms are often similar in all domains of life. The most serious type of damage, double stranded DNA breaks, are for example repaired in conceptually similar ways in both bacteria and eukaryotes. LÄS MER

  5. 4. Hidden Markov models for remote protein homology detection

    Författare :Markus Wistrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Protein classification; hidden Markov model; homology detection; G proteincoupled receptor;

    Sammanfattning : Genome sequencing projects are advancing at a staggering pace and are daily producing large amounts of sequence data. However, the experimental characterization of the encoded genes and proteins is lagging far behind. LÄS MER

  7. 5. Towards Mosquitocides for Prevention of Vector-Borne Infectious Diseases : discovery and Development of Acetylcholinesterase 1 Inhibitors

    Författare :Sofie Knutsson; Anna Linusson; Fredrik Almqvist; Andreas Larsson; Ulf Nilsson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mosquito; vector-borne diseases; vector control; insecticide; acetylcholinesterase; medicinal chemistry; high-throughput screening; organic synthesis; homology modeling; structure activity relationship; structure selectivity relationship; datorlingvistik; computational linguistics; organisk kemi; Organic Chemistry;

    Sammanfattning : Diseases such as malaria and dengue impose great economic burdens and are a serious threat to public health, with young children being among the worst affected. These diseases are transmitted by mosquitoes, also called disease vectors, which are able to transmit both parasitic and viral infections. LÄS MER