Sökning: "histone deacetylase"
Visar resultat 1 - 5 av 53 avhandlingar innehållade orden histone deacetylase.
1. Engineering cytosolic acetyl-CoA metabolism in Saccharomyces cerevisiae
Sammanfattning : A Saccharomyces cerevisiae strain carrying deletions in all three pyruvate decarboxylase genes (also called Pdc negative yeast) represents a non-ethanol producing platform strain for biochemical production. However, it cannot grow on glucose as the sole carbon source due to the lack of cytosolic acetyl-CoA for lipid biosynthesis. LÄS MER
2. The Interaction of the Adenovirus E1B-55K Protein with a Histone Deacetylase Complex: Its Importance in Regulation of P53 Protein Functions
Sammanfattning : The human tumour suppressor protein p53 is an effective inhibitor of cell growth, by inducing cell cycle arrest and apoptosis. However, p53-induced cell growth inhibition can be detrimental for virus multiplication. Therefore, viruses encode for proteins, which can interfere with the functions of the p53 protein. LÄS MER
3. The IGF-axis in liver disease : modulation of expression by histone deacetylase inhibitors
Sammanfattning : The Insulin-like growth factor (IGF) axis is composed of a family of ligands, receptors and binding proteins with important functions in the regulation of cell growth, apoptosis, survival, migration and development. The liver is a major provider of several of the IGF-axis members. LÄS MER
4. Activity and mechanism of action of histone deacetylase inhibitors in synovial sarcoma
Sammanfattning : Synovial sarcoma is a rare but aggressive paediatric soft tissue sarcoma that is driven by the genomic rearrangement t(X;18)(p11.2;q11.2). The resulting fusion protein, SS18- SSX, exhibits oncogenic properties through protein-protein interactions that alter gene transcriptions and chromatin remodelling. LÄS MER
5. Characterization of proteins involved in differentiation and apoptosis of human leukemia and epithelial cancer cells
Sammanfattning : Today, cancer is understood as an epigenetic as well as a genetic disease. The main epigenetic hallmarks of the cancer cell are DNA methylation and histone modifications. The latter changes may be an optimal target for novel anticancer agents. LÄS MER