Sökning: "heterozygosity"
Visar resultat 1 - 5 av 93 avhandlingar innehållade ordet heterozygosity.
1. Dispersal, inbreeding and fitness in natural populations
Sammanfattning : To evaluate how inbreeding affects the viability of small populations, it is crucial to determine what constitutes a population (i.e., the number of breeders in local patches and the degree of dispersal), and also to estimate the reproductive consequences of philopatry and emigration. LÄS MER
2. Infidelity in Birds – Causes and Consequences of Extra-pair Paternity
Sammanfattning : Forty years ago, more than 90% of bird species were classified as monogamous and not very exciting systems for studies of e.g. sexual selection. LÄS MER
3. Molecular Pathogenesis of Cervical Carcinoma : Analysis of Clonality, HPV16 Sequence Variations and Loss of Heterozygosity
Sammanfattning : A previous model of morphological pathogenesis assumed that cervical carcinoma is of monoclonal origin and progresses through multiple steps from normal epithelium via CINS into invasive carcinomas. The aim of this study was to investigate the molecular mechanism of pathogenesis of cervical neoplasia. LÄS MER
4. Genotoxic effects of systemic chemotherapy in cancer patients, with special focus on the relation between MSI, LOH and development of secondary cancers
Sammanfattning : Systemic chemotherapy results in both phenotypic and genotypic side effects. Genotoxicity posed by chemotherapy is a major concern since it induces DNA damage and instability in the patients’ genome. LÄS MER
5. Targeting allelic loss in colorectal cancer
Sammanfattning : Targeted cancer therapy exploits molecular differences between tumor and normal cells to selectively kill cancer cells. Whereas targeting of activated oncogenes has proved clinically useful, few current therapies exploit loss-of-function mutations in tumor suppressor genes or in the genome at large. LÄS MER