Sökning: "heat shock protein HSP"

Visar resultat 1 - 5 av 23 avhandlingar innehållade orden heat shock protein HSP.

  1. 1. Pathophysiology of blood-brain barrier, brain edema and cell injury following hyperthermia : New role of heat shock protein, nitric oxide and carbon monoxide : an experimental study in rat using light and electron microscopy

    Författare :Hari Shanker Sharma; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; blood-brain barrier; heat stress; hyperthermia; brain edema; serotonin; nitric oxide; carbon monoxide; heat shock protein; glial fibrillary acidic protein; myelin basic protein; opioids; histamine; catecholamines; naloxone; indomethacin; p-CPA; electron microscopy; immunocytochemistry; Cellbiologi; Cell biology; Cellbiologi; Human Anatomy; anatomi;

    Sammanfattning : This thesis deals with the molecular mechanisms of hyperthermia induced brain damage in rats. The results clearly establish that hyperthermia caused by 4 h heat stress at 38° C is associated with a breakdown of the blood-brain barrier (BBB) permeability which seems to be instrumental in causing brain edema and cell injury. LÄS MER

  3. 2. Heat shock proteins as vaccine adjuvants

    Författare :Khaleda Rahman Qazi; Carmen Fernández; Qijun Chen; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heat shock protein; vaccine; adjuvant; BCG; Immunology; Immunologi;

    Sammanfattning : New efficient vaccines against infectious diseases are in demand. Some important factors impeding the vaccine development are the poor immunogenicity and the MHC restriction of the immune responses to a number of antigens. LÄS MER

  4. 3. Combined structural methods to characterize an oligomeric small heat shock protein Hsp21

    Författare :Gudrun Rutsdottir; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Small heat shock proteins; chaperones; crosslinking mass spectrometry; Stable isotope labeling; quantification; small angle X-ray scattering; cryo-electron microscopy; combined structural methods; plant stress;

    Sammanfattning : Small heat shock proteins (sHsps) are found in all organisms and evolved early in the history of life, prior to the divergence of the three domains of life (Archaea, Bacteria, and Eukarya). Their malfunction is connected to several different diseases in humans, such as Alzheimer’s and Parkinson’s disease. LÄS MER

  5. 4. Interstitial laser thermotherapy (ILT) of an adenocarcinoma implanted into rat liver - methodology and effects

    Författare :Kjell Ivarsson; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi; heat shock protein HSP ; tumour immunology; resection; liver; adenocarcinoma; local treatment; monitoring; Interstitial laser thermotherapy; feedback control;

    Sammanfattning : Local treatment of a tumour is of interest from a number of perspectives. It is focused on reducing the tumour volume with minimal trauma, inducing tumour immunity and is a potential component of a combination therapy against tumours. LÄS MER

  7. 5. Meticulous control of the T3SS of Yersinia is essential for full virulence

    Författare :Ann-Catrin Björnfot; Hans Wolf-Watz; Kelly T. Hughes; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Yersinia; type III secretion; YscU; substrate specificity switch; heat shock proteins; VagH; methyltransferase; virulence; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The type III secretion system (T3SS) of pathogenic Yersinia pseudotuberculosis is involved in virulence. The syringe-like secretion system spans both bacterial membranes and is responsible for the ability of Yersinia to transfer toxic proteins (Yop proteins) into the eukaryotic target cell. LÄS MER