Sökning: "haplotypes"

Visar resultat 1 - 5 av 158 avhandlingar innehållade ordet haplotypes.

  1. 1. Genetic variation in the folate receptor-alpha and methylenetetrahydrofolate reductase genes as determinants of plasma homocysteine concentrations

    Författare :Anna Böttiger; Torbjörn Nilsson; Henrik Zetterberg; Örebro universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Folate receptor-alpha; Folate; FOLR1; Haplotypes; Homocysteine; Methylenetetrahydrofolate reductase; MTHFR; Polymorphisms; Pyrosequencing®; SSCP; Medicine; Medicin; Biomedicin; Biomedicine;

    Sammanfattning : Elevated total plasma homocysteine (tHcy) is a risk factor for cardiovascular disease and neurocognitive disease such as dementia. The B vitamins folate and B12 are the main de terminants of tHcy. tHcy concentration can also be affected by mutations in genes coding for receptors, enzymes and transporters important in the metabolism of Hcy. LÄS MER

  3. 2. Intrahepatic cholestasis of pregnancy

    Författare :Anna Glantz; Göteborgs universitet; []
    Nyckelord :Intrahepatic cholestasis of pregnancy ICP ; pruritus; fetal risk; ursodeoxycholic acid; dexamethasone; ABCB4-gene; haplotypes; sulphated progesterone metabolites;

    Sammanfattning : Intrahepatic cholestasis of pregnancy (ICP) is a condition that has been reported to be associated with an increased fetal risk. A prospective study of ICP was conducted in the Västra Götaland region of Sweden between February 1, 1999 and January 31, 2002. LÄS MER

  4. 3. Polyploid Phylogenetics in Plants: Insights on non-model organisms in Fabaceae and Malvaceae

    Författare :Jonna S. Eriksson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Diploidization; genome duplication; haplotypes; Hibisceae; Hibiscus; homoeologues; high-throughput sequencing; Pavonia; Malvaceae; polyploidization;

    Sammanfattning : Genome duplication is a common phenomenon in angiosperms and advances in sequencing technologies and bioinformatics is now revealing its prevalence and significance. In a polyploidization event all genes in a genome are doubled. LÄS MER

  5. 4. Factors Influencing Evolution to Antimalarial Drug Resistance in Plasmodium falciparum in Sudan and The Gambia

    Författare :Amany Kheir; Göte Swedberg; Susanne Kerje; Hamza Babiker; Staffan Svärd; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cross-mating; fitness; microsatellite haplotypes; mosquito infectivity; Infectious diseases; Infektionssjukdomar; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Drug resistance is a major obstacle to management and control of malaria and currently progressing at a rapid rate across Africa. This thesis has examined factors influencing evolution of resistant P. falciparum at two sites in Africa, including parasite migration, cross mating and fitness cost of resistance. LÄS MER

  7. 5. The evolution of sexual dimorphism and its genetic underpinnings

    Författare :Philipp Kaufmann; Elina Immonen; Tim Connallon; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Sexual conflict; sex-specific dominance; maintenance of genetic variance; sexual antagonism; sex chromosomes; Y haplotypes; artificial selection; sexual dimorphism; Callosobruchus maculatus; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Sammanfattning : Sexual dimorphism often constitutes the largest phenotypic variance within species but it is puzzling how sexual dimorphisms evolve because most of the genome is shared between the sexes. Sexually antagonistic (SA) selection on a shared genome sets the stage for intralocus sexual conflict. LÄS MER